RESUMO
Survival patterns of NBL/Up mice exposed to 675-800 R of total-body x-radiation depended on direction and rate of exposure. Homogeneous dual exposures administered at 126 R/minute were more effective than those administered at 63 R/minute. Dorsal and dual exposures at 63 R/minute were equally effective, while absorption reduced the effectiveness of ventral exposures. Since cellular repair of hematopoietic tissue was initiated only during exposure, increased homogeneity without increased exposure rate would not increase effectiveness. With rate, direction, and homogeneity influencing the effectiveness of total-body exposures, fallacies inherent in converting total-body exposures to absorbed tissue dose became apparent.
Assuntos
Radioterapia/métodos , Irradiação Corporal Total/métodos , Animais , Transferência de Energia , Feminino , Camundongos , Radioterapia/efeitos adversos , Dosagem Radioterapêutica , Irradiação Corporal Total/efeitos adversosAssuntos
Computadores , Atenção à Saúde , Modelos Teóricos , Regionalização da Saúde , Geografia , Planejamento Hospitalar , Humanos , Estados UnidosRESUMO
A model is described that predicts hospital census and computes, for each day, the number of elective admissions that will maximize the census over the short run, subject to constraints on the probability of overflow. Where a computer is available the model provides detailed predictions of census in units as small as 10 beds; used with manual computation the model allows production of tables of the recommended numbers of elective admissions to the hospital as a whole. The model has been tested in five hospitals and is part of the admissions system in two of them; implementation is described, and the results obtained are discussed.
