RESUMO
Chronic, not acute treatment with carbamazepine enhanced the hypothermic response to a dose of clonidine thought to exert its predominant effect on the presynaptic alpha 2-autoreceptor. This response was markedly elevated both during the course of and 10 days after the discontinuation of treatment with carbamazepine. Sensitivity to clonidine returned to baseline 10 to 21 days after the discontinuation of treatment. Carbamazepine is the first treatment for the disorders of mood that has been demonstrated to enhance a physiological response to clonidine. The authors discuss the theoretical relationship between increased sensitivity of the presynaptic alpha 2-autoreceptor and the usefulness of carbamazepine in the treatment of bipolar disorder.
Assuntos
Regulação da Temperatura Corporal/efeitos dos fármacos , Carbamazepina/farmacologia , Clonidina/farmacologia , Norepinefrina/fisiologia , Receptores Adrenérgicos alfa 2/efeitos dos fármacos , Animais , Regulação da Temperatura Corporal/fisiologia , Carbamazepina/farmacocinética , Esquema de Medicação , Masculino , Ratos , Ratos Sprague-Dawley , Receptores Adrenérgicos alfa 2/fisiologiaRESUMO
The ABO records of 392 blood donors in the Isle of Bute, Scotland, showed a significant excess of group A and decrease of group O compared with data from the adjacent mainland. A survey by questionnaire to explain these observations assessed the representative nature of the donor panel as a sample of the Bute population, with respect to sex, age, occupation and origin by birthplace and parental birthplace. The reported motivations first prompting the Bute panel to donate blood were analysed, especially those liable to introduce bias into the results. It was concluded that: the informative 318 donors were not an atypical sample; inclusion of Younger Kindred enhanced the group A frequency; inclusion of donors with knowledge of their blood groups before enrolment as donors introduced a counter-bias in favour of group O; the raised group A frequency of the Incomers to the island was probably attributable to admixture of an English population with a non-Bute Scottish population; the Brandanes could represent a small indigenous island population in which the incidence of group A has become high, but, as numbers were small, a chance observation could not be excluded.
