Can Prediction of Functional Outcome after Stroke Be Improved by Adding Fibrinogen to Prognostic Model?

BACKGROUND: Several studies demonstrated that elevated plasma fibrinogen level is associated with poor functional outcome after ischemic stroke. It remains, however, unclear if prediction of functional outcome after stroke can be improved by adding fibrinogen to prognostic model. We aimed to determine the prognostic value of plasma fibrinogen for the prediction of functional outcome after ischemic stroke. METHODS: We retrospectively analyzed the data of 727 ischemic stroke patients (median age: 70; 48% men). The functional outcome was assessed 1 month after stroke onset using modified Rankin Scale. Unfavorable outcome was defined as modified Rankin Scale score higher than 2. Using C-statistic and reclassification measures (net reclassification improvement-NRI and integrated discrimination improvement-IDI), we compared the predictive abilities of 2 models. The first model contained stroke severity and age, and the second one included fibrinogen in addition. RESULTS: After adjusting for age and stroke severity, plasma fibrinogen level higher than 2.95 g/L was associated with unfavorable outcome (OR: 1.80, 95% CI: 1.20-2.72, P < .01). The addition of fibrinogen did not lead to an improvement in predictive ability of the model. C-statistic did not differ between models (.90 versus .90, P = .34). The categorical NRI was .01 (P = .66) and the IDI was .006 (P = .08). CONCLUSIONS: The addition of fibrinogen to predictive model including age and stroke severity does not improve discrimination between favorable and unfavorable outcomes after ischemic stroke.

Improvement of survival in Polish stroke patients is related to reduced stroke severity and better control of risk factors: the Krakow Stroke Database.

INTRODUCTION: In the last decade, the stroke mortality rate in Poland significantly decreased. We hypothesised that stroke severity, the major determinant of outcome, is lowered in Polish stroke patients. MATERIAL AND METHODS: We compared the stroke severity in two cohorts of first-ever ischaemic stroke patients admitted within 24 h after stroke onset to the Department of Neurology, Jagiellonian University, Krakow in the years 1994-2000 and 2008-2012. To assess stroke severity we used the National Institute of Health Stroke Scale (NIHSS). We defined mild stroke as an NIHSS score ≤ 4. RESULTS: We included 816 patients hospitalised in the years 1994-2000 and 569 patients hospitalised in the years 2008-2012. NIHSS score on admission was higher in the former (mean: 12.0 ±7.0 vs. 8.0 ±6.0, p < 0.01), and the frequency of mild stroke was higher in the latter (12.7% vs. 41.8%, p < 0.01). Although the frequency of hypertension (67.3% vs. 81.2%, p < 0.01), diabetes mellitus (20.8% vs. 26.4%, p = 0.02) and atrial fibrillation (20.7% vs. 26.2%, p = 0.02) was higher in patients hospitalised in the years 2008-2012, the systolic and diastolic blood pressure values and the frequency of fasting hyperglycaemia were lower in this cohort. This cohort also less frequently suffered from hypercholesterolaemia (25.4% vs. 16.3%, p < 0.01). CONCLUSIONS: Reduced stroke severity is associated with better recognition and control of risk factors and explains the improvement of survival in Polish stroke patients.

Hyperfibrinogenemia predicts long-term risk of death after ischemic stroke.

In stroke patients higher levels of plasma fibrinogen are associated with increased risk of unfavourable functional outcome and short-term mortality. The aim of our study was to determine the relationship between plasma fibrinogen level and long-term risk of death in ischemic stroke patients. Seven hundred thirty six patients (median age 71; 47.1% men) admitted to the stroke unit within 24 h after stroke were included. Plasma fibrinogen level was measured on day 1 of hospitalisation. Hyperfibrinogenemia was defined as plasma fibrinogen concentration >3.5 g/L. The maximal follow-up period was 84 months. Hyperfibrinogenemia was found in 25.0% of patients. On multivariate logistic regression analysis, after adjustment for age, stroke severity, atrial fibrillation, smoking, white blood cell count, fever, in-hospital pneumonia and hyperglycemia, hyperfibrinogenemia was associated with increased case fatality (HR 1.71, 95% CI 1.29-2.26, P < 0.01). Hyperfibrinogenemia predicts the long-term risk of death in ischemic stroke patients.

The sustained increase of plasma fibrinogen during ischemic stroke predicts worse outcome independently of baseline fibrinogen level.

Hyperfibrinogenemia at the beginning of ischemic stroke is associated with poor outcome. We hypothesized that the sustained increase of plasma fibrinogen during stroke predicts outcome independently of baseline fibrinogen concentration. We included 266 patients with first-ever ischemic stroke in whom plasma fibrinogen level was measured on days 1, 7, and 14. The sustained fibrinogen's increase was defined as the persistent elevation of fibrinogen's concentration on days 7 and 14 by at least 20 % compared to the level on day 1. The functional outcome on day 30 was assessed using modified Rankin Scale (mRS). Favorable outcome was defined as mRS 0-1. The sustained increase of fibrinogen was found in 17 % of patients. On multivariate logistic regression analysis adjusted for age, NIHSS score, baseline fibrinogen >2.66 mmol/L, presence of infection, and hyperglycemia, the sustained fibrinogen's level was associated with reduced chance of favorable outcome (OR: 0.17, 95 % CI: 0.06-0.48, P < 0.01).