Assuntos
Doença Hepática Induzida por Substâncias e Drogas/etiologia , Epirubicina/farmacocinética , Tamoxifeno/efeitos adversos , Adenocarcinoma/tratamento farmacológico , Adenocarcinoma/secundário , Neoplasias Ósseas/tratamento farmacológico , Neoplasias Ósseas/secundário , Neoplasias da Mama , Feminino , Humanos , Pessoa de Meia-IdadeRESUMO
Sera from 367 patients with rheumatoid arthritis (RA) and from 102 patients with other non-organ-specific (NOS) autoimmune diseases were examined for the presence of organ-specific (OS) autoantibodies. The incidence of these OS autoantibodies was not increased in patients with NOS autoimmune diseases with the exception of thyroglobulin antibodies, which were significantly more frequent in RA (P less than 0.001) and in Sjögren's syndrome (P less than 0.05) patients than in normal controls. Investigation of 169 patients with OS autoimmune diseases did not reveal an increased prevalence of NOS autoantibodies. In RA patients, OS autoantibodies correlated with NOS autoantibodies (P less than 0.04) and with HLA-DR3 antigen (P less than 0.01).
Assuntos
Artrite Reumatoide/imunologia , Autoanticorpos/análise , Doenças Autoimunes/imunologia , Adolescente , Adulto , Idoso , Feminino , Antígenos HLA-DR/imunologia , Antígeno HLA-DR3 , Humanos , Masculino , Pessoa de Meia-Idade , Especificidade de Órgãos , Síndrome de Sjogren/imunologia , Tireoglobulina/imunologiaRESUMO
Ten early rheumatoid arthritis (RA) patients and 10 healthy volunteers were given 200 mg of ketoprofen daily for 8 days. Polymorphonuclear cell functional studies were performed just before and immediately after this treatment. In RA patients, increased chemotactic index and adherence returned to normal after this short-term treatment whilst reduced phagocytosis and bacterial function were not significantly modified by the drug. In healthy volunteers, no significant effect was shown. In addition, ketoprofen diminished the chemotactic activity induced by zymosan in RA patients and also in healthy volunteer plasma.
