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1.
AJP Rep ; 5(2): e193-5, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26495183

RESUMO

Introduction Acute fatty liver of pregnancy (AFLP) is a rare but potentially fatal condition occurring in the third trimester or early postpartum period. It is characterized by microvesicular fatty infiltration of the liver. Clinically, the three most prominent derangements in women with AFLP are hepatic dysfunction, renal insufficiency, and impaired coagulation. AFLP is associated with an increased incidence of morbidity and mortality in neonates, though the exact cause for this remains unclear. Deficiency of vitamin K in patients with liver disease has been widely reported. Case Description We present a unique case of severe intracranial bleeding because of the early vitamin K deficiency in a neonate whose mother had AFLP along with accompanying renal insufficiency. Conclusion We suggest that monitoring infants born to mothers with AFLP, for vitamin K deficiency bleeding will help reduce morbidity and mortality in these infants.

2.
Pediatr Radiol ; 36(7): 677-81, 2006 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16547698

RESUMO

BACKGROUND: Congenital heart disease (CHD) is a significant cause of morbidity and mortality in pediatric patients. Traditional teaching holds that specific types of CHD can be diagnosed on the chest radiograph (CXR) through pattern recognition. OBJECTIVE: To determine the accuracy of radiologists in detecting CHD on the CXR. MATERIALS AND METHODS: This study was a blinded retrospective review of chest radiographs from 281 patients (<12 years) by five pediatric radiologists from three institutions. Thirteen groups were evaluated that included 12 categories of CHD and a control group of patients without heart disease. Radiographs were assessed for heart size, heart and mediastinal shape and vascularity. Clinical information, angiography, echocardiograms and surgery were used as the gold standard for definitive diagnosis. RESULTS: The average accuracy of the five readers in distinguishing normal from CHD patients was 78% (range of 72% to 82%). The overall measure of accuracy in distinguishing specific congenital cardiac lesions among 13 groups of patients was 71% (range of 63% to 79%). CONCLUSION: CXR alone is not diagnostic of specific cardiac lesions, with a low accuracy of only 71%. We believe that less emphasis should be placed on the use of radiographs alone in diagnosing specific congenital cardiac lesions.


Assuntos
Cardiopatias Congênitas/diagnóstico por imagem , Criança , Pré-Escolar , Angiografia Coronária , Diagnóstico Diferencial , Ecocardiografia , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Curva ROC , Estudos Retrospectivos
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