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1.
Ann R Coll Surg Engl ; 96(2): e1-4, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-24780653

RESUMO

Pasteurella multocida is a rare cause of prosthetic joint infection. This infection generally follows significant animal contact, usually licks and scratches. We report a case of P multocida infection that was treated with linezolid with salvage of the implant. Linezolid is generally active against Gram-positive organisms only with the exception of Pasteurella, which is Gram-negative. We extensively review the previous reported cases of implant infection with P multocida.


Assuntos
Acetamidas/uso terapêutico , Antibacterianos/uso terapêutico , Prótese do Joelho/efeitos adversos , Oxazolidinonas/uso terapêutico , Infecções por Pasteurella/tratamento farmacológico , Pasteurella multocida , Infecções Relacionadas à Prótese/tratamento farmacológico , Idoso , Artroplastia do Joelho/efeitos adversos , Feminino , Humanos , Prótese do Joelho/microbiologia , Linezolida , Osteoartrite do Joelho/cirurgia , Infecções Relacionadas à Prótese/microbiologia , Terapia de Salvação
2.
Rev Sci Instrum ; 85(4): 043506, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24784606

RESUMO

First simultaneous measurements of deuterium-deuterium (DD) and deuterium-tritium neutrons from deuterium plasmas using a Single crystal Diamond Detector are presented in this paper. The measurements were performed at JET with a dedicated electronic chain that combined high count rate capabilities and high energy resolution. The deposited energy spectrum from DD neutrons was successfully reproduced by means of Monte Carlo calculations of the detector response function and simulations of neutron emission from the plasma, including background contributions. The reported results are of relevance for the development of compact neutron detectors with spectroscopy capabilities for installation in camera systems of present and future high power fusion experiments.

3.
Phys Rev Lett ; 107(20): 205002, 2011 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-22181739

RESUMO

The spectral broadening of characteristic γ-ray emission peaks from the reaction (12)C((3)He,pγ)(14)N was measured in D((3)He) plasmas of the JET tokamak with ion cyclotron resonance heating tuned to the fundamental harmonic of (3)He. Intensities and detailed spectral shapes of γ-ray emission peaks were successfully reproduced using a physics model combining the kinetics of the reacting ions with a detailed description of the nuclear reaction differential cross sections for populating the L1-L8 (14)N excitation levels yielding the observed γ-ray emission. The results provide a paradigm, which leverages knowledge from areas of physics outside traditional plasma physics, for the development of nuclear radiation based methods for understanding and controlling fusion burning plasmas.

4.
Rev Sci Instrum ; 81(10): 10E136, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-21061488

RESUMO

Notwithstanding the advances of the past decades, significant developments are still needed to satisfactorily diagnose "burning plasmas." D­T plasmas indeed require a series of additional measurements for the optimization and control of the configuration: the 14 MeV neutrons, the isotopic composition of the main plasma, the helium ash, and the redistribution and losses of the alpha particles. Moreover a burning plasma environment is in general much more hostile for diagnostics than purely deuterium plasmas. Therefore, in addition to the development and refinement of new measuring techniques, technological advances are also indispensable for the proper characterization of the next generation of devices. On JET an integrated program of diagnostic developments, for JET future and in preparation for ITER, has been pursued and many new results are now available. In the field of neutron detection, the neutron spectra are now routinely measured in the energy range of 1­18 MeV by a time of flight spectrometer and they have allowed studying the effects of rf heating on the fast ions. A new analysis method for the interpretation of the neutron cameras measurements has been refined and applied to the data of the last trace tritium campaign (TTE). With regard to technological upgrades, chemical vapor deposition diamond detectors have been qualified both as neutron counters and as neutron spectrometers, with a potential energy resolution of about one percent. The in situ calibration of the neutron diagnostics, in preparation for the operation with the ITER-like wall, is also promoting important technological developments. With regard to the fast particles, for the first time the temperature of the fast particle tails has been obtained with a new high purity Germanium detector measuring the gamma emission spectrum from the plasma. The effects of toroidal Alfven eigenmodes modes and various MHD instabilities on the confinement of the fast particles have been determined with a combination of gamma ray cameras, neutral particle analyzers, scintillator probe, and Faraday cups. From a more technological perspective, various neutron filters have been tested to allow measurement of the gamma ray emission also at high level of neutron yield.

5.
Rev Sci Instrum ; 81(10): 10D321, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-21058454

RESUMO

A new high efficiency, high resolution, fast γ-ray spectrometer was recently installed at the JET tokamak. The spectrometer is based on a LaBr3(Ce) scintillator coupled to a photomultiplier tube. A digital data acquisition system is used to allow spectrometry with event rates in excess of 1 MHz expected in future JET DT plasmas. However, at the lower rates typical of present day experiments, digitization can degrade the energy resolution of the system, depending on the algorithms used for extracting pulse height information from the digitized pulses. In this paper, the digital and analog spectrometry methods were compared for different experimental conditions. An algorithm based on pulse shape fitting was developed, providing energy resolution equivalent to the traditional analog spectrometry method.

6.
Rev Sci Instrum ; 79(10): 10E504, 2008 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-19068503

RESUMO

Activation studies were performed in JET with new in-vessel activation monitors. Though primarily dedicated to R&D in the challenging issue of lost diagnostics for ITER, which is being addressed at JET with several techniques, these monitors provide for both neutron and charged particle fluences. A set of samples with different orientation with respect to the magnetic field is transported inside the torus by means of a manipulator arm (in contrast with the conventional JET activation system with pneumatic transport system). In this case, radionuclides with longer half-life were selected and ultralow background gamma-ray measurements were needed. The irradiation was closer to the plasma and this potentially reduces the neutron scattering problem. This approach could also be of interest for ITER, where the calibration methods have yet to be developed. The MCNP neutron transport model for JET was modified to include the activation probe and so provide calculations to help assess the new data. The neutron induced activity on the samples are well reproduced by the calculations.

7.
Rev Sci Instrum ; 79(10): 10E524, 2008 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-19068513

RESUMO

In fusion plasmas gamma ray emission is caused by reactions of fast particles, such as fusion alpha particles, with impurities. Gamma ray spectroscopy at JET has provided valuable diagnostic information on fast fuel as well as fusion product ions. Improvements of these measurements are needed to fully exploit the flux increase provided by future high power experiments at JET and ITER. Limiting aspects are, for instance, the count rate capability due to a high neutron/gamma background combined with slow detector response and a modest energy resolution due to the low light yield of the scintillators. This paper describes the solutions developed for achieving higher energy resolution, signal to background, and time resolution. The detector design is described based on the new BrLa3 scintillator crystal. The paper will focus on hardware development, including a photomultiplier tube capable of stable operation at counting rate as high as 1 MHz, the magnetic shielding, and the fast digital data acquisition system.

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