Musical experience is linked to enhanced dimension-selective attention to pitch and increased primary weighting during suprasegmental categorization.

Speech perception requires the integration of evidence from acoustic cues across multiple dimensions. Individuals differ in their cue weighting strategies, that is, the weight they assign to different dimensions during speech categorization. In two experiments, we investigate musical training as one potential predictor of individual differences in prosodic cue weighting strategies. Attentional theories of speech categorization suggest that prior experience with the task-relevance of a particular dimension leads that dimension to attract attention. Experiment 1 tested whether musicians and nonmusicians differed in their ability to selectively attend to pitch and loudness in speech. Compared to nonmusicians, musicians showed enhanced dimension-selective attention to pitch but not loudness. Experiment 2 tested the hypothesis that musicians would show greater pitch weighting during prosodic categorization due to prior experience with the task-relevance of pitch cues in music. Listeners categorized phrases that varied in the extent to which pitch and duration signaled the location of linguistic focus and phrase boundaries. During linguistic focus categorization, musicians upweighted pitch compared to nonmusicians. During phrase boundary categorization, musicians upweighted duration relative to nonmusicians. These results suggest that musical experience is linked with domain-general enhancements in the ability to selectively attend to certain acoustic dimensions in speech. As a result, musicians may place greater perceptual weight on a single primary dimension during prosodic categorization, while nonmusicians may be more likely to choose a perceptual strategy that integrates across multiple dimensions. These findings support attentional theories of cue weighting, which suggest attention influences listeners' perceptual weighting of acoustic dimensions during categorization. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Salient sounds distort time perception and production.

The auditory world is often cacophonous, with some sounds capturing attention and distracting us from our goals. Despite the universality of this experience, many questions remain about how and why sound captures attention, how rapidly behavior is disrupted, and how long this interference lasts. Here, we use a novel measure of behavioral disruption to test predictions made by models of auditory salience. Models predict that goal-directed behavior is disrupted immediately after points in time that feature a high degree of spectrotemporal change. We find that behavioral disruption is precisely time-locked to the onset of distracting sound events: Participants who tap to a metronome temporarily increase their tapping speed 750 ms after the onset of distractors. Moreover, this response is greater for more salient sounds (larger amplitude) and sound changes (greater pitch shift). We find that the time course of behavioral disruption is highly similar after acoustically disparate sound events: Both sound onsets and pitch shifts of continuous background sounds speed responses at 750 ms, with these effects dying out by 1,750 ms. These temporal distortions can be observed using only data from the first trial across participants. A potential mechanism underlying these results is that arousal increases after distracting sound events, leading to an expansion of time perception, and causing participants to misjudge when their next movement should begin.

Dimension-selective attention and dimensional salience modulate cortical tracking of acoustic dimensions.

Some theories of auditory categorization suggest that auditory dimensions that are strongly diagnostic for particular categories - for instance voice onset time or fundamental frequency in the case of some spoken consonants - attract attention. However, prior cognitive neuroscience research on auditory selective attention has largely focused on attention to simple auditory objects or streams, and so little is known about the neural mechanisms that underpin dimension-selective attention, or how the relative salience of variations along these dimensions might modulate neural signatures of attention. Here we investigate whether dimensional salience and dimension-selective attention modulate the cortical tracking of acoustic dimensions. In two experiments, participants listened to tone sequences varying in pitch and spectral peak frequency; these two dimensions changed at different rates. Inter-trial phase coherence (ITPC) and amplitude of the EEG signal at the frequencies tagged to pitch and spectral changes provided a measure of cortical tracking of these dimensions. In Experiment 1, tone sequences varied in the size of the pitch intervals, while the size of spectral peak intervals remained constant. Cortical tracking of pitch changes was greater for sequences with larger compared to smaller pitch intervals, with no difference in cortical tracking of spectral peak changes. In Experiment 2, participants selectively attended to either pitch or spectral peak. Cortical tracking was stronger in response to the attended compared to unattended dimension for both pitch and spectral peak. These findings suggest that attention can enhance the cortical tracking of specific acoustic dimensions rather than simply enhancing tracking of the auditory object as a whole.

Sorting through the impact of familiarity when processing vocal identity: Results from a voice sorting task.

The present article reports on one experiment designed to examine the importance of familiarity when processing vocal identity. A voice sorting task was used with participants who were either personally familiar or unfamiliar with three speakers. The results suggested that familiarity supported both an ability to tell different instances of the same voice together, and to tell similar instances of different voices apart. In addition, the results suggested differences between the three speakers in terms of the extent to which they were confusable, underlining the importance of vocal characteristics and stimulus selection within behavioural tasks. The results are discussed with reference to existing debates regarding the nature of stored representations as familiarity develops, and the difficulty when processing voices over faces more generally.

The cystine/glutamate antiporter system xc- drives breast tumor cell glutamate release and cancer-induced bone pain.

Bone is one of the leading sites of metastasis for frequently diagnosed malignancies, including those arising in the breast, prostate and lung. Although these cancers develop unnoticed and are painless in their primary sites, bone metastases result in debilitating pain. Deeper investigation of this pain may reveal etiology and lead to early cancer detection. Cancer-induced bone pain (CIBP) is inadequately managed with current standard-of-care analgesics and dramatically diminishes patient quality of life. While CIBP etiology is multifaceted, elevated levels of glutamate, an excitatory neurotransmitter, in the bone-tumor microenvironment may drive maladaptive nociceptive signaling. Here, we establish a relationship between the reactive nitrogen species peroxynitrite, tumor-derived glutamate, and CIBP. In vitro and in a syngeneic in vivo model of breast CIBP, murine mammary adenocarcinoma cells significantly elevated glutamate via the cystine/glutamate antiporter system xc. The well-known system xc inhibitor sulfasalazine significantly reduced levels of glutamate and attenuated CIBP-associated flinching and guarding behaviors. Peroxynitrite, a highly reactive species produced in tumors, significantly increased system xc functional expression and tumor cell glutamate release. Scavenging peroxynitrite with the iron and mangano-based porphyrins, FeTMPyP and SRI10, significantly diminished tumor cell system xc functional expression, reduced femur glutamate levels and mitigated CIBP. In sum, we demonstrate how breast cancer bone metastases upregulate a cystine/glutamate co-transporter to elevate extracellular glutamate. Pharmacological manipulation of peroxynitrite or system xc attenuates CIBP, supporting a role for tumor-derived glutamate in CIBP and validating the targeting of system xc as a novel therapeutic strategy for the management of metastatic bone pain.

The Functional Role of Neural Oscillations in Non-Verbal Emotional Communication.

Effective interpersonal communication depends on the ability to perceive and interpret nonverbal emotional expressions from multiple sensory modalities. Current theoretical models propose that visual and auditory emotion perception involves a network of brain regions including the primary sensory cortices, the superior temporal sulcus (STS), and orbitofrontal cortex (OFC). However, relatively little is known about how the dynamic interplay between these regions gives rise to the perception of emotions. In recent years, there has been increasing recognition of the importance of neural oscillations in mediating neural communication within and between functional neural networks. Here we review studies investigating changes in oscillatory activity during the perception of visual, auditory, and audiovisual emotional expressions, and aim to characterize the functional role of neural oscillations in nonverbal emotion perception. Findings from the reviewed literature suggest that theta band oscillations most consistently differentiate between emotional and neutral expressions. While early theta synchronization appears to reflect the initial encoding of emotionally salient sensory information, later fronto-central theta synchronization may reflect the further integration of sensory information with internal representations. Additionally, gamma synchronization reflects facilitated sensory binding of emotional expressions within regions such as the OFC, STS, and, potentially, the amygdala. However, the evidence is more ambiguous when it comes to the role of oscillations within the alpha and beta frequencies, which vary as a function of modality (or modalities), presence or absence of predictive information, and attentional or task demands. Thus, the synchronization of neural oscillations within specific frequency bands mediates the rapid detection, integration, and evaluation of emotional expressions. Moreover, the functional coupling of oscillatory activity across multiples frequency bands supports a predictive coding model of multisensory emotion perception in which emotional facial and body expressions facilitate the processing of emotional vocalizations.