RESUMO
A series of 7-methyl-9-(substituted arylamino)imidazo[4,5-f]quinolines was prepared and screened against four varieties of bacteria. The compounds possessed antibacterial activity against both Gram-positive and Gram-negative organisms.
Assuntos
Aminoquinolinas/síntese química , Antibacterianos/síntese química , Aminoquinolinas/farmacologia , Fenômenos Químicos , Química , Corynebacterium/efeitos dos fármacos , Escherichia coli/efeitos dos fármacos , Gardnerella vaginalis/efeitos dos fármacos , Staphylococcus aureus/efeitos dos fármacosRESUMO
A series of 1-[[(5-nitrofuranyl)methylene]amino]-4- and/or -5-substituted 2-imidazolidinones was prepared utilizing three different reaction sequences. The structure of 4, the product derived from 4-methyl-2-imidazolidinone (2a), was verified by synthesis using an alternate, unequivocal route. The levo isomer l-4 was prepared by a series of reactions starting with L(+)-2-amino-1-propanol (l-10). All of the nitrofurans were examined for potential use as chemotherapeutic agents for urinary tract infections. Based on the high level of activity in the urine and the in vitro antibacterial activity (MIC) 4, l-4, and 16 are considered to be the most active as urinary tract agents.