1.
Dokl Biochem Biophys
; 462: 158-62, 2015.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26163209
2.
Biofizika
; 60(6): 1180-5, 2015.
Artigo
em Russo
| MEDLINE
| ID: mdl-26841514
RESUMO
The results of the numerical simulation of the end-diastolic, end-systolic and stroke volumes of the left ventricle of the heart are presented. The simulation was based on a published simple kinetic model of cardiac muscle and approximation of the ventricle geometry with thick-wall cylinder where the fibre orientation varied linearly from sub-epicardium towards sub-endocardium. Blood flow was modelled with a liner compartment model. This simplified approach provides correct dependencies of the stroke volume on the pre- and afterload, namely end-diastolic pressure and peripheral resistance. The calculations show that the stroke volume is independent of arterial compliance and blood inertia.