[Viability of tissues of the extremities and surgical tactics in stage IV arteriosclerosis obliterans]. / Zhiznesposobnost' tkanei konechnosti i khirurgicheskaia taktika pri IV stadii obliteriruiushchego ateroskleroza.

Amputation of the extremity was performed in 26 of 52 patients with the IV stage obliterating atherosclerosis. Clinical severity of the disease was confronted with results of special investigations. Three groups of such patients are described: with traumatic necroses, with ischemic necroses and with necrotic ischemia (criteria of its irreversibility are presented). Surgical tactics of treatment in the first group of patients may include sympathectomy with necrectomy. The outcome of treatment of the second group patients is determined by the efficiency of reconstructive operations. Amputation of the extremity is indicated to patients of the third group.

[Disorders of the "lipid peroxidation-antioxidant" system and ways of their correction after transplantation of vascularized tissue complexes]. / Narusheniia v sisteme "perekisnoe okislenie lipidov"-anti-oksidanty" i puti ikh korrektsii pri transplantatsii krovosnabzhaemykh kompleksov tkanei.

An experimental investigation in 40 rabbits and 13 dogs has shown that arrest of blood flow in tissues is accompanied by activation of lipid peroxidation processes with reduced activity of the antioxidant system. Tissue anoxia during 4h sharply activates lipid peroxidation processes which is considerably aggravated after early performance of oxygenobarotherapy sessions (1h after revascularization). Relatively late sessions of oxygenobarotherapy (10h after the reestablishment of bloodflow) are not accompanied by activation of lipid peroxidation and decrease of the level of antioxidants of lipid nature, alpha-tocopherol acetate has a marked antioxidation effect and enhances tissue survival after anoxia.