[Subjective and objective evaluation of treating schizophrenia with classic or atypical drugs]. / Subiektywna i obiektywna ocena leczenia schizofrenii lekami klasycznymi i atypowymi.

Subjective and objective evaluation of pharmacological treatment was made in 105 schizophrenic in-patients. PANSS and Calgary scale as well as Van Putten scale were used. Fifty-four percent of subjects received classic neuroleptics and 46%--new atypical drugs for an average period of 8 weeks. The severity of schizophrenic symptoms during treatment as well as subjective evaluation of first effects of the drug did not differ among subjects treated with classic or atypical drugs. Depressive symptoms decreased significantly during treatment with atypicals but not with classic drugs. Also a significant decrease of depression was found under olanzapine treatment. The severity of neuroleptic-induced side-effects did not differ in both groups. Neurological side effects were more prominent in subjects after 4 weeks of therapy with risperidone, in comparison to patients receiving olanzapine. Forty-seven per-cent of patients showed a dysphoric reaction to the first dose of medication. After treatment with atypical drugs, better subjective evaluation of pharmacotherapy correlated with less severe general and depressive schizophrenia symptoms. Patients' better evaluation of olanzapine treatment correlated with less severe schizophrenic general symptomatology. The subjective evaluation of treatment was better in patients with less severe neurological side-effects of atypical drugs (including olanzapine but not risperidone) and less severe autonomic side-effects of classic drugs. The evaluation of pharmacotherapy made by patients' family members did not correlate with subjects' opinions after distribution of the first dose of the drugs, but correlated significantly with patients' opinion after 8-weeks of treatment. The treatment received by the patients was judged better by the family members if less severe neurological side-effects were present.

[The evaluation of subjective quality of life in patients with schizophrenia or depression]. / Próba analizy subiektywnej oceny jakosci zycia pacjentów z rozpoznaniem schizofrenii lub depresji.

Subjective evaluation of the quality of life was studied in 53 schizophrenics (hospitalized, from the day-hospital, and from the rehabilitation unit) and in 12 depressed patients before and after pharmacological treatment or rehabilitation. The self-evaluation questionnaire SF-36 was used. The subjective quality of life of depressive patients at baseline was low in comparison to the schizophrenics. The best improvement of subjective quality of life after the treatment was found in hospitalized schizophrenic patients. Evaluation of the quality of life both before and after treatment/rehabilitation did not correlate with doctors' estimation of the severity of their illness. Depressive patients expressed more negative opinion regarding their physical condition and social activity than did the schizophrenics. The positive opinion on patients' health status correlated positively with good evaluation of patients' physical condition and good performance at home or work.