RESUMO
Authors report on local mitomycin-C (MTM-C) therapy applied subsequent to the treatment by means of Nd-YAG laser in 59 superficial (Ta-T1) bladder neoplasms. Relapse-rate in the neoplasms could be reduced by using MTM-C accompanied by minor side-effects. Seventy-two % of patients have been free from relapse for the mean 44-month follow-up period. Authors also suggest that laser therapy may favourably be completed by local chemoprophylaxis in "high-risk" type superficial bladder neoplasms.
Assuntos
Carcinoma de Células de Transição/prevenção & controle , Carcinoma de Células de Transição/cirurgia , Fotocoagulação a Laser , Mitomicina/administração & dosagem , Neoplasias da Bexiga Urinária/prevenção & controle , Neoplasias da Bexiga Urinária/cirurgia , Adulto , Idoso , Quimioterapia Adjuvante , Feminino , Humanos , Injeções Intralesionais , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/prevenção & controleRESUMO
In our animal experiments we used a chemical agent (dibutylnitrosamine) to induce urinary bladder tumor in rats, then this was implanted under the dorsal skin of rats of the same strain to gain a standard tumor preparation. The histological effects of electrocoagulation and Nd-Yag laser coagulation were compared in rat striated muscle, liver, intact rat urinary bladder and in our standard tumor preparation. The histological changes suggested that laser coagulation has advantages over electrocoagulation for inducing deep and homogenous necrosis in intact and tumorous tissues.
Assuntos
Carcinoma de Células de Transição/cirurgia , Eletrocoagulação , Fotocoagulação a Laser , Neoplasias da Bexiga Urinária/patologia , Neoplasias da Bexiga Urinária/cirurgia , Animais , Carcinoma de Células de Transição/induzido quimicamente , Carcinoma de Células de Transição/patologia , Feminino , Transplante de Neoplasias , Ratos , Ratos Endogâmicos F344 , Neoplasias da Bexiga Urinária/induzido quimicamenteRESUMO
Authors describe a new analytical method for monitoring the treatment of vesicular tumors. Chromatographic analysis of the polyamine content of the eluent allows differential diagnostic judgement of the malignity of the laser treated tumorous tissue. The practical applicability of the method is demonstrated and evaluated on the basis of the analysis of 88 clinical cases.
Assuntos
Poliaminas Biogênicas/análise , Carcinoma de Células de Transição/química , Carcinoma de Células de Transição/cirurgia , Terapia a Laser , Neoplasias da Bexiga Urinária/química , Neoplasias da Bexiga Urinária/cirurgia , Idoso , Cromatografia Líquida de Alta Pressão , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Putrescina/análise , Espermidina/análise , Espermina/análiseRESUMO
The urological complications of surgical interventions are discussed on the basis of the authors' clinical material collected over six years. Mainly fistulas and inflammatory complications occurred due to gynaecological operations performed by abdominal penetration. The possibilities and incidence of complications, as well as the diagnostic methods used for their detection and the applied therapies are reviewed. The importance of the proper choice of restituting surgical interventions is stressed. Complete anatomical and functional restoration and preservation of the organ are attempted. Attention is called to the importance and possibilities of preventing complications due to injuries. In the reduction of the incidence of urological complications after gynaecological operations, beside prevention, a close co-operation with the urologist is necessary as well as post-operative check-ups even in symptomless cases.
