RESUMO
Serum IFN-gamma levels were studied in adult patients with chronic oral candidosis, associated with Candida albicans infection. In the group of patients, mean serum IFN-gamma levels (2.74+/-465 pg ml(-1)) were significantly lower than in healthy individuals (9.80+/-1.68 pg ml(-1)). In analysis of the C. albicans strains isolated from lesions in the patients, their ability was estimated to secrete proteinases. Serum IFN-gamma levels failed to correlate with infections induced by proteinase-producing C. albicans. The results allowed us to conclude that Candida infection may be associated with an insufficient IFN-gamma response of the host, which seems to result in chronic conversion of candidosis. Proteolytic activity of C. albicans strains in vitro is not related to virulence of the strains.
Assuntos
Candidíase Bucal/imunologia , Interferon gama/sangue , Adulto , Candida albicans , Candidíase Bucal/sangue , Doença Crônica , Feminino , Soronegatividade para HIV , Humanos , Imunoglobulina A/sangue , Imunoglobulina G/sangue , Imunoglobulina M/sangue , Masculino , Pessoa de Meia-Idade , Valores de ReferênciaRESUMO
Basing on observations of a group of patients treated in Oral Mucosa Diseases and Industrial Dentistry Department analysis of some cases with clinical symptoms of oral cavity mycosis, without any clinical symptoms but with subjective complaints pointing out the possibility of mycotic infection existence and with other diseases of oral mucosa from the point of view of additional mycotic infections has been performed. Clinical examinations, cytological and microbiological examinations have been carried out. Cytological examination has been proved useful for quick determination of oral cavity mycotic infections that has been confirmed by microbiological examinations. Early detection of the infection was precipitating the treatment procedure and improving the disease prognosis.
