Peri-ictal heart rate changes in patients with epilepsy.

Background: Heart rate (HR) changes associated with seizures are promising biomarkers in epilepsy. Aims: The aim of our study is to reveal possible HR changes in the peri-ictal period. Methods: Long-term video-EEG monitorization records of generalized and focal epilepsy patients were reviewed. HRs were calculated in the pre-ictal (2 min before the first seizure activity in EEG), ictal (the time from the first seizure activity on the EEG to the end of the seizure), and in the interictal period (at least 2 h before or 12 h after the seizure). Interictal, pre-ictal, and ictal HRs were compared with each other. In addition, it was investigated whether peri-ictal HR changes differ between generalized and focal seizure patients. Results: Focal motor seizures were observed in 21, and generalized tonic-clonic seizures were observed in 18 of 39 (22 female and 17 male) patients studied. HRs in the pre-ictal and ictal periods were significantly higher than in the interictal period. This significant increase in HR was validated separately in both focal and generalized seizure groups and was not different between the two groups. Conclusion: Our study supports previous studies showing the presence of increased peri-ictal HR and also provides new insights by comparing focal and generalized motor seizures. We think that our findings may contribute to the development of early warning signs in epilepsy patients.

[A case of bronchial leiomyoma]. / Ein Fall von bronchialem Leiomyom.

Pulmonary leiomyomas are the least common benign tumors of the lung. These tumors originate from smooth muscles of the bronchial walls, peripheral small airways, or from perivascular smooth muscles. It is reported that the diagnosis of the tumor has been established bronchoscopically and proved with thoracotomy. The characteristics of the tumor and treatment modalities are discussed.

Observations of nuclear reactors on satellites with a balloon-borne gamma-ray telescope.

Gamma rays at energies of 0.3 to 8 megaelectron volts (MeV) were detected on 15 April 1988 from four nuclear-powered satellites including Cosmos 1900 and Cosmos 1932 as they flew over a double Compton gamma-ray telescope. The observations occurred as the telescope, flown from a balloon at an altitude of 35 kilometers from Alice Springs, Australia, searched for celestial gamma-ray sources. The four transient signals were detected in 30 hours of data. Their time profiles show maxima with durations of (21 +/- 1) and (27 +/- 1) seconds (half-width at half maximum) for the lower two satellites and (85 +/- 5) and (113 +/- 7) seconds for the remaining two. Their durations place the origin of the two shorter signals at orbital radii of 260(+40)(-60) and 260 +/- 60 km above the earth and the two longer at 800(+100)(-300) and 800(+250)(-300) kilometers. Their luminosities for energies >0.3 MeV are then (6.1 +/- 1.5) x 10(15), (3.9 +/- 1.0) x 10(15), (1.10 +/- 0.28) x 10(16), and (1.30 +/- 0.32) x 10(16) photons per second. The imaging of the strongest signal indicates a southeastern direction passing nearly overhead. The energy spectrum can be fit to an exponential with index 2.4 +/- 1.4. These transient events add to the already large backgrounds for celestial gamma ray sources.