RESUMO
Se ha sugerido que el virus del papiloma humano (HPV) puede originar cáncer de pulmón no microcítico (NSCLC). La tasa de infección HPV es mayor en NSCLC de asiáticos, no fumadores, con adenocarcinoma o respuesta a inhibidores tirosín-cinasa del receptor del factor de crecimiento epidérmico (EGFR-TKI). Hemos explorado retrospectivamente la relación entre mutaciones EGFR o respuesta a EGFR-TKI e infección HPV en 40pacientes con NSCLC, considerando el impacto del sexo, de la edad, del subtipo histológico, del tabaquismo y del tipo de muestra. La tasa de infección HPV fue del 2,5%, y no influía ninguna variable analizada, aunque el escaso tamaño muestral no permite conclusiones definitivas. La tasa de infección HPV en NSCLC debería revisarse en pacientes con mutaciones EGFR o tendencia a presentarlas(AU)
It has been suggested that human papillomavirus (HPV) could participate in the development of non-small-cell lung cancer (NSCLC). A higher HPV infection rate has been reported in the NSCLC samples from Asian non-smoker patients, with adenocarcinomas or responders to EGFR tyrosine kinase inhibitors (EGFR-TKI). We explored a potential relationship between EGFR mutation, response to EGFR-TKI and HPV infection in Western NSCLC patients. We retrospectively analyzed 40 NSCLC samples and the impact of age, gender, histology, tobacco habit and sample type. HPV infection rate was 2.5% and it was not statistically modified by any analyzed variable, although the limited sample size did not provide definitive conclusions. The rate of HPV infection in NSCLC should be studied in patients with EGFR mutations or a tendency towards presenting them(AU)
Assuntos
Humanos , Masculino , Feminino , Carcinoma Pulmonar de Células não Pequenas/complicações , Carcinoma Pulmonar de Células não Pequenas/diagnóstico , Genes erbB-1 , Genes erbB-1/genética , Poluição por Fumaça de Tabaco/efeitos adversos , Fumar/efeitos adversos , Papillomavirus Humano 6 , Papillomavirus Humano 6/patogenicidade , Papillomaviridae/genética , Papillomaviridae/isolamento & purificação , Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico , Carcinoma Pulmonar de Células não Pequenas/fisiopatologia , Carcinoma Pulmonar de Células não Pequenas , Receptores ErbB , Receptores ErbB/uso terapêutico , Estudos RetrospectivosRESUMO
It has been suggested that human papillomavirus (HPV) could participate in the development of non-small-cell lung cancer (NSCLC). A higher HPV infection rate has been reported in the NSCLC samples from Asian non-smoker patients, with adenocarcinomas or responders to EGFR tyrosine kinase inhibitors (EGFR-TKI). We explored a potential relationship between EGFR mutation, response to EGFR-TKI and HPV infection in Western NSCLC patients. We retrospectively analyzed 40 NSCLC samples and the impact of age, gender, histology, tobacco habit and sample type. HPV infection rate was 2.5% and it was not statistically modified by any analyzed variable, although the limited sample size did not provide definitive conclusions. The rate of HPV infection in NSCLC should be studied in patients with EGFR mutations or a tendency towards presenting them.
