RESUMO
66 patients of 40-77 age group with atherosclerosis were studied. The observation period made up 4 weeks. The patients were divided into two groups. Group I- experimental group (50 patients) and group II-control group (16 patients) The patients of both groups were given standard therapy, but the patients of group I were additionally given 200mg soybean flavonoid supplement (daily dose 100mg. in capsules two times a day after meals). Clinical observation showed that the patients had no adverse reactions due to intake of the natural food supplement. Compared to the control patients better dynamics of clinical signs was observed in experimental group: reduction of chest pain intensity, arrhythmia and breathlessness, increase of tolerance to physical load, manifested of normalisation arterial hypertension and reduction of heart rate. Biochemical analysis showed an antiatherogenic and hypolipidemic effect of the soybean flavonoid supplement. Statistically reliable increase of NO; reduction of general peripherial vascular resistance and improvement of systolic function. Therefore it can be concluded that given biologically active supplement can be used in the treatment of atherosclerosis as an effective therapeutic tool.
Assuntos
Aterosclerose , Proteínas Alimentares/uso terapêutico , Suplementos Nutricionais , Flavonoides/uso terapêutico , Óxido Nítrico/biossíntese , Proteínas de Soja/uso terapêutico , Adulto , Idoso , Aterosclerose/sangue , Aterosclerose/dietoterapia , Aterosclerose/fisiopatologia , Ecocardiografia Doppler , Espectroscopia de Ressonância de Spin Eletrônica , Feminino , Seguimentos , Ventrículos do Coração/diagnóstico por imagem , Ventrículos do Coração/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Contração Miocárdica/efeitos dos fármacos , Óxido Nítrico/sangue , Resultado do Tratamento , Resistência Vascular/efeitos dos fármacosRESUMO
It has been stated that decreased dispersion of QT interval (QTd) on 12 lead ECG is associated with successful thrombolysis (TH) in acute myocardial infarction but it is not clear whether QTd can predict early successful TH. The goal of the investigation was to evaluate significance of QTd and QT interval variability between adjacent precordial leads (QTdl) for prediction of successful early TH in acute coronary syndrome (ACS). Two groups of patients after 6 hours from the beginning of acute coronary attack with elevation of ST segment on ECG were under investigation: I group -- 26 patients with resolution of ST> or =70% after 60-90 min from the starting of TH and II group -- 21 patients with no resolution of ST. QTd was defined as the difference between maximal and minimal QT interval and QTd as the difference between adjacent precordial ECG leads. QTd is a marker of successful TH but does not predict its efficiency, QTde<50 predicted TH with 80% sensitivity, 85% specificity and 87% positive predictive value.
Assuntos
Doença das Coronárias , Eletrocardiografia , Fibrinolíticos/uso terapêutico , Síndrome do QT Longo/epidemiologia , Síndrome do QT Longo/fisiopatologia , Doença Aguda , Doença das Coronárias/tratamento farmacológico , Doença das Coronárias/epidemiologia , Doença das Coronárias/fisiopatologia , Diagnóstico Precoce , Feminino , Humanos , Síndrome do QT Longo/diagnóstico , Masculino , Pessoa de Meia-Idade , Prognóstico , Terapia TrombolíticaRESUMO
Clinical and experimental evidence closely link malignant ventricular arrhythmia with increased dispersion of refractoriness and thus electrical heterogeneity in different kinds of heart diseases. Most increased dispersion of refractoriness is due to inhomogenous action potential duration in adjacent areas, decreased local conduction velocity or both. The article focuses on ectopic ventricular activity and on QT interval variability in adjacent segments on standard ECG in patients with acute coronary syndrome. The adjacent QT dispersion was defined as a difference between two adjacent leads. Seventy nine patients aged 54+/-6,5 in 6 hour interval after the attack with elevation of ST segments on ECG were studied. Fifteen patients aged 48+/-7 without elevation of ST segment on ECG served as control subjects. Patients were allocated to two groups: one included patients with 1-2 ectopic degree; group two included patients with 3-5 ectopic degree. In patients with acute coronary syndrome QT max and QTd was significantly higher than in control subjects (p<0,05). The increase of ventricular ectopic degree is linked with the increased adjacent QT dispersion.
Assuntos
Eletrocardiografia , Isquemia Miocárdica/diagnóstico , Doença Aguda , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Isquemia Miocárdica/etiologia , SíndromeAssuntos
Adaptação Fisiológica , Lisossomos/fisiologia , Aceleração/efeitos adversos , Adaptação Fisiológica/efeitos dos fármacos , Adaptação Fisiológica/efeitos da radiação , Medicina Aeroespacial , Animais , Câmaras de Exposição Atmosférica , Sistema Nervoso Central/efeitos dos fármacos , Sistema Nervoso Central/efeitos da radiação , Sistema Nervoso Central/ultraestrutura , Cães , Hipóxia/fisiopatologia , Imunidade Inata/efeitos dos fármacos , Imunidade Inata/fisiologia , Imunidade Inata/efeitos da radiação , Fígado/efeitos dos fármacos , Fígado/efeitos da radiação , Fígado/ultraestrutura , Lisossomos/efeitos dos fármacos , Lisossomos/enzimologia , Lisossomos/efeitos da radiação , Masculino , Oxigênio/administração & dosagem , Ratos , Voo Espacial , Baço/efeitos dos fármacos , Baço/efeitos da radiação , Baço/ultraestrutura , Vibração/efeitos adversosRESUMO
Biologically active substances exhibiting the radioprotective effect were formed in liver tissue after treatment with hypoxia and with electromagnetic irradiation of ultrahigh frequency. The protective factor was found to be among protein or peptide fractions. Possible mechanisms of formation and action of the biologically active substance are discussed.
Assuntos
Lesões Experimentais por Radiação/metabolismo , Estresse Fisiológico/metabolismo , Animais , Hipóxia Celular , Hidrólise , Fígado/metabolismo , Fígado/efeitos da radiação , Masculino , RatosRESUMO
It was shown that biologically active substances formed in the liver tissue under the effect of hypoxia and SHF electromagnetic radiation produce a radioprotective effect when administered 15 min before exposure and have no protective effect when administered after irradiation.