Improved on-line benchtop 31P NMR reaction monitoring via Multi-Resonance SHARPER.

On-line reaction monitoring of hydrogenation reactions featuring oxygen-sensitive organometallic complexes is done via a 31P benchtop NMR spectrometer using the Multi-Resonance Sensitive Homogeneous And Resolved PEaks in Real time (MR-SHARPER) sequence. Signal enhancement generated by MR-SHARPER enables monitoring of reactivity on the order of minutes that could not be followed with traditional 31P{1H} NMR detection.