RESUMO
Data concerning patterns of dissemination and recurrence as well as the end results of treatment of 148 cases of vulvar cancer were used to develop adequate therapeutic options for the disease versus age and extent of tumor. Prophylactic and therapeutic removal of the inguinal and femoral lymph nodes, high radicality of vulvo- and lymphadenectomy, and fast electron irradiation assured a better prognosis.
Assuntos
Adenocarcinoma/terapia , Carcinoma de Células Escamosas/terapia , Neoplasias Vulvares/terapia , Adenocarcinoma/radioterapia , Adenocarcinoma/cirurgia , Carcinoma de Células Escamosas/radioterapia , Carcinoma de Células Escamosas/cirurgia , Feminino , Humanos , Excisão de Linfonodo , Pessoa de Meia-Idade , Vulva/patologia , Neoplasias Vulvares/patologia , Neoplasias Vulvares/radioterapiaRESUMO
The incidences of combination of koilocytosis and dysplasias of squamous epithelium of skin-mucous integument of vulva in 120 patients with kraurosis and leukoplakia and 166 patients with carcinoma of external genitalia (at the distance of 3-4 cm from the tumour) are studied. Vulva tissue of 100 women of the same age dying from non-tumourous conditions served as control. The increase of the koilocytosis incidence was observed at various stages of carcinogenesis (slight dysplasia--mild dysplasia--severe dysplasia--preinvasive carcinoma). koilocytes are not found in the invasive carcinoma. It is suggested to consider koilocytosis as one of additional morphologic signs of the risk of vulva carcinoma. The disappearance of koilocytes which are markers of the viral cell alteration in invasive carcinomas allows one to regard a viral damage of the vulva epithelium as one of the cocarcinogenic influences responsible for the development of squamous cell carcinoma.
Assuntos
Lesões Pré-Cancerosas/patologia , Neoplasias Vulvares/patologia , Epitélio/patologia , Feminino , Humanos , Lesões Pré-Cancerosas/microbiologia , Fatores de Risco , Viroses/complicações , Viroses/epidemiologia , Viroses/patologia , Neoplasias Vulvares/microbiologiaRESUMO
Based on the analysis of clinico-morphological findings in 302 patients with cancer of the vulva, the author pinpoints further the prognostic value of the factors characterizing the peculiar features of primary tumor and its local and regional spread. The 5-year survival was noted in 56.3%. The prognosis is found to be worse in a decreased degree of tumor histological differentiation, its localization in the clitoris region, in endophytic growth, the increased perimeter and infiltration of underlying tissues, and if regional lymph nodes are involved by metastases.
