A rotating fast bipolar wind and disk system around the B[e]-type star MWC 922.

We present interferometric observations with the Atacama Large Millimeter Array (ALMA) of the free-free continuum and recombination line emission at 1 and 3 mm of the "Red Square Nebula" surrounding the B[e]-type star MWC922. The unknown distance to the source is usually taken to be d=1.7-3 kpc. The unprecedented angular resolution ( up to ∼ 0 . ″ 02 ) and exquisite sensitivity of these data unveil, for the first time, the structure and kinematics of the emerging, compact ionized region at its center. We imaged the line emission of H30α and H39α, previously detected with single-dish observations, as well as of H51ϵ, H55γ, and H63δ, detected for the first time in this work. The line emission is seen over a full velocity range of ~180 km s-1 arising in a region of diameter < 0 . ″ 14 (less than a few hundred au) in the maser line H30α, which is the most intense transition reported here. We resolve the spatio-kinematic structure of a nearly edge-on disk rotating around a central mass of ~10 M ⊙ (d=1.7 kpc) or ~18 M ⊙ (d=3 kpc), assuming Keplerian rotation. Our data also unveil a fast (~100 km s-1) bipolar ejection (a jet?) orthogonal to the disk. In addition, a slow (<15 km s-1) wind may be lifting off the disk. Both, the slow and the fast winds are found to be rotating in a similar manner to the ionized layers of the disk. This represents the first empirical proof of rotation in a bipolar wind expanding at high velocity (~100 km s-1 ). The launching radius of the fast wind is found to be <30-51 au i.e., smaller than the inner rim of the ionized disk probed by our observations. We believe that the fast wind is actively being launched, probably by a disk-mediated mechanism in a (accretion?) disk around a possible compact companion. We have modelled our observations using the radiative transfer code MORELI. This has enabled us to describe with unparalleled detail the physical conditions and kinematics in the inner layers of MWC 922, which has revealed itself as an ideal laboratory for studying the interplay of disk rotation and jet-launching. Although the nature of MWC 922 remains unclear, we believe it could be a ~15 M ⊙ post-main sequence star in a mass-exchanging binary system. If this is the case, a more realistic value of the distance may be d~3 kpc.

(sub)Millimeter Emission Lines of Molecules in Born-again Stars⋆.

CONTEXT: Born-again stars offer us a unique possibility of studying the evolution of the circumstellar envelope of evolved stars in human timescales. To present, most of the observations of the circumstellar material in these stars have been limited to study the relatively hot gas and dust. In other evolved stars, the emission from rotational transitions of molecules, such as CO, is commonly used to study the cool component of their circumstellar envelopes. Thus, the detection and study of molecular gas in born-again stars would be of great importance to understand their composition and chemical evolution. In addition, the molecular emission would be an invaluable tool to explore the physical conditions, kinematics and formation of asymmetric structures in the circumstellar envelopes of these evolved stars. However, until now, all attempts to detect molecular emission from the cool material around born-again stars have failed. AIMS: We searched for emission from rotational transitions of molecules in the hydrogen-deficient circumstellar envelopes of born-again stars to explore the chemical composition, kinematics, and physical parameters of the relatively cool gas. METHODS: We carried out observations using the APEX and IRAM 30m telescopes to search for molecular emission toward four well studied born-again stars, V4334 Sgr, V605 Aql, A30 and A78, that are thought to represent an evolutionary sequence. RESULTS: We detected for the first time emission from HCN and H13CN molecules toward V4334 Sgr, and CO emission in V605 Aql. No molecular emission was detected above the noise level toward A30 and A78. The detected lines exhibit broad linewidths ≳150 km s-1, which indicates that the emission comes from gas ejected during the born-again event, rather than from the old planetary nebula. A first estimate of the H12CN/H13CN abundance ratio in the circumstellar environment of V4334 Sgr is ≈3, which is similar to the value of the 12C/13C ratio measured from other observations. We derived a rotational temperature of T rot=13±1 K, and a total column density of N HCN=1.6±0.1×1016 cm-2 for V4334 Sgr. This result sets a lower limit on the amount of hydrogen that was ejected into the wind during the born-again event of this source. For V605 Aql, we obtained a lower limit for the integrated line intensities I 12C/I 13C>4.

Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome.

BACKGROUND: Down syndrome, or trisomy 21, is a complex genetic disease resulting from the presence of 3 copies of chromosome 21. The origin of the extra chromosome is maternal in 95% of cases and is due to the failure of normal chromosomal segregation during meiosis. Although advanced maternal age is a major risk factor for trisomy 21, most children with Down syndrome are born to mothers <30 y of age. OBJECTIVE: On the basis of evidence that abnormal folate and methyl metabolism can lead to DNA hypomethylation and abnormal chromosomal segregation, we hypothesized that the C-to-T substitution at nucleotide 677 (677C-->T) mutation of the methylenetetrahydrofolate reductase (MTHFR) gene may be a risk factor for maternal meiotic nondisjunction and Down syndrome in young mothers. DESIGN: The frequency of the MTHFR 677C-->T mutation was evaluated in 57 mothers of children with Down syndrome and in 50 age-matched control mothers. Ratios of plasma homocysteine to methionine and lymphocyte methotrexate cytotoxicity were measured as indicators of functional folate status. RESULTS: A significant increase in plasma homocysteine concentrations and lymphocyte methotrexate cytotoxicity was observed in the mothers of children with Down syndrome, consistent with abnormal folate and methyl metabolism. Mothers with the 677C-->T mutation had a 2.6-fold higher risk of having a child with Down syndrome than did mothers without the T substitution (odds ratio: 2.6; 95% CI: 1.2, 5.8; P < 0.03). CONCLUSION: The results of this initial study indicate that folate metabolism is abnormal in mothers of children with Down syndrome and that this may be explained, in part, by a mutation in the MTHFR gene.