Quantitative evaluation by measurement and modeling of the variations in dose distributions deposited in mobile targets.

The objective of this study is to quantitatively evaluate variations of dose distributions deposited in mobile target by measurement and modeling. The effects of variation in dose distribution induced by motion on tumor dose coverage and sparing of normal tissues were investigated quantitatively. The dose distributions with motion artifacts were modeled considering different motion patterns that include (a) motion with constant speed and (b) sinusoidal motion. The model predictions of the dose distributions with motion artifacts were verified with measurement where the dose distributions from various plans that included three-dimensional conformal and intensity-modulated fields were measured with a multiple-diode-array detector (MapCheck2), which was mounted on a mobile platform that moves with adjustable motion parameters. For each plan, the dose distributions were then measured with MapCHECK2 using different motion amplitudes from 0-25 mm. In addition, mathematical modeling was developed to predict the variations in the dose distributions and their dependence on the motion parameters that included amplitude, frequency and phase for sinusoidal motions. The dose distributions varied with motion and depended on the motion pattern particularly the sinusoidal motion, which spread out along the direction of motion. Study results showed that in the dose region between isocenter and the 50% isodose line, the dose profile decreased with increase of the motion amplitude. As the range of motion became larger than the field length along the direction of motion, the dose profiles changes overall including the central axis dose and 50% isodose line. If the total dose was delivered over a time much longer than the periodic time of motion, variations in motion frequency and phase do not affect the dose profiles. As a result, the motion dose modeling developed in this study provided quantitative characterization of variation in the dose distributions induced by motion, which can be employed in radiation therapy to quantitatively determine the margins needed for treatment planning considering dose spillage to normal tissue.

Photopatterning of polybutadiene substrates by interferometric ultraviolet lithography: fabrication of phospholipid microarrays.

Gratings are written holographically with low power (10 mW/cm(2)) 244 nm UV light on thin films of polybutadiene rubber polymer. The increase of hydrophilicity-wettability of polybutadiene films is measured over UV-exposed regions. Sequential fabrication of two orthogonal gratings results in hydrophilic microarrays having applications as functionalized substrates for immobilizing biomolecules. This is demonstrated by immobilizing a phospholipid in a microarray pattern.