RESUMO
Basra, southern Iraq, was mapped for haemoglobinopathies and glucose-6-phosphate dehydrogenase (G6PD) deficiency. Of 1064 couples aged 14-60 years recruited from the Public Health Laboratory, 49 had beta-thalassaemia trait, 69 had sickle-cell trait, 2 had haemoglobin D trait, 2 had haemoglobin C trait and 1 had high persistent fetal haemoglobin. Carriers of major beta-globin disorders comprised 11.48%. G6PD deficiency was detected in 133 individuals (12.5%). Only 10 couples (0.94%) were at risk of having children affected with either sickle-cell disease or beta-thalassaemia major. These defects constitute a real health problem and necessitate a management plan and public health education for early diagnosis and therapy.
Assuntos
Deficiência de Glucosefosfato Desidrogenase/epidemiologia , Deficiência de Glucosefosfato Desidrogenase/genética , Hemoglobinopatias/epidemiologia , Hemoglobinopatias/genética , Adolescente , Adulto , Feminino , Hemoglobina Fetal/genética , Frequência do Gene/genética , Triagem de Portadores Genéticos , Aconselhamento Genético , Testes Genéticos , Deficiência de Glucosefosfato Desidrogenase/prevenção & controle , Educação em Saúde , Doença da Hemoglobina C/epidemiologia , Doença da Hemoglobina C/genética , Hemoglobinopatias/prevenção & controle , Hemoglobinas Anormais/genética , Humanos , Iraque/epidemiologia , Masculino , Pessoa de Meia-Idade , Epidemiologia Molecular , Avaliação das Necessidades , Vigilância da População , Prevalência , Características de Residência/estatística & dados numéricos , Fatores de Risco , Traço Falciforme/epidemiologia , Traço Falciforme/genética , Talassemia beta/epidemiologiaRESUMO
Basra, southern Iraq, was mapped for haemoglobinopathies and glucose-6-phosphate dehydrogenase [G6PD] deficiency. Of 1064 couples aged 14-60 years recruited from the Public Health Laboratory, 49 had beta-thalassaemia trait, 69 had sickle-cell trait, 2 had haemoglobin D trait, 2 had haemoglobin C trait and 1 had high persistent fetal haemoglobin. Carriers of major beta-globin disorders comprised 11.48%. G6PD deficiency was detected in 133 individuals [12.5%]. Only 10 couples [0.94%] were at risk of having children affected with either sickle-cell disease or beta-thalassaemia major. These defects constitute a real health problem and necessitate a management plan and public health education for early diagnosis and therapy
