1.
Org Lett
; 16(8): 2080-3, 2014 Apr 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24697786
RESUMO
An enantioselective Reformatsky reaction has been developed for the reaction of ethyl dibromofluoroacetate (1) with an imine. This method represents the first ligand-promoted imino-Reformatsky approach to use a halofluoroacetate. The use of an amino alcohol ligand allowed for the preparation of enantioenriched α-bromo-α-fluoro-ß-lactams in good yields with enantioselectivities up to 96% ee. This process also provided access to ß-lactam rings bearing two stereogenic centers.