[Therapeutic pathomorphism of Ewing's tumor]. / Terapevticheskii patomorfoz opukholi Iunga.

Pathomorphosis of Ewing's tumors after the combined treatment is studied with the use of light and electron microscopy, DNA-flow cytometry. Necrosis and apoptosis of tumor cells produced by the therapy are characterized. Therapeutic forms of tumor cells representing hyperaneuploid population delayed at the G2-level of the cell cycle are described.

[Cytoplasmic receptors of steroid hormones and clinico-morphological characteristics of skin melanoma]. / Tsitoplazmaticheskie retseptory steroidnykh gormonov i kliniko-morfologicheskie osobennosti melanomy kozhy.

Receptors of estrogens (ER), progesterone (PR), glucocorticoids (GR) and androgens (AR) were assayed in samples obtained from 142 patients with malignant melanoma. GR were observed most often (57% of cases), the percentage being significantly lower for ER (25%) and PR (18%) and extremely low for AR (4%). The occurrence of GR was significantly higher in metastasis to lymph nodes (69%) and soft tissue (67%) as compared to primary tumor (39%). It was higher in acro-lentiginous melanoma (83%) than in superficially extending (30%) or nodular one (33%). GR occurrence rose with the increase in level of invasion (from 30% for level III to 71% for level V) and tumor thickness. In application of adjuvant chemotherapy, patients with GR--negative tumors tended to survive better than those with GR--positive tumors whereas in the chemotherapy-naive group, GR--positive tumors carried better prognosis.