A Multi-Organ Nucleus Segmentation Challenge.

Generalized nucleus segmentation techniques can contribute greatly to reducing the time to develop and validate visual biomarkers for new digital pathology datasets. We summarize the results of MoNuSeg 2018 Challenge whose objective was to develop generalizable nuclei segmentation techniques in digital pathology. The challenge was an official satellite event of the MICCAI 2018 conference in which 32 teams with more than 80 participants from geographically diverse institutes participated. Contestants were given a training set with 30 images from seven organs with annotations of 21,623 individual nuclei. A test dataset with 14 images taken from seven organs, including two organs that did not appear in the training set was released without annotations. Entries were evaluated based on average aggregated Jaccard index (AJI) on the test set to prioritize accurate instance segmentation as opposed to mere semantic segmentation. More than half the teams that completed the challenge outperformed a previous baseline. Among the trends observed that contributed to increased accuracy were the use of color normalization as well as heavy data augmentation. Additionally, fully convolutional networks inspired by variants of U-Net, FCN, and Mask-RCNN were popularly used, typically based on ResNet or VGG base architectures. Watershed segmentation on predicted semantic segmentation maps was a popular post-processing strategy. Several of the top techniques compared favorably to an individual human annotator and can be used with confidence for nuclear morphometrics.

Melanoma recognition in dermoscopy images using lesion's peripheral region information.

BACKGROUND AND OBJECTIVES: Melanoma is one of the most dangerous forms of skin cancer, but it has a high survival rate if diagnosed on time. The first diagnostic approach in melanoma recognition is to visually assess the lesion through dermoscopic images. Computer-aided diagnosis systems for melanoma recognition has attracted a lot of attention in the last decade and proved to be helpful in that area. Methods for skin lesions analysis usually involves three main steps: lesion segmentation, feature extraction, and features classification. Extracting highly discriminative features from the lesion has a great impact on the recognition task. In this paper, we are seeking a lesion recognition system that incorporates these highly discriminative features. METHODS: For segmentation step, we use contour propagation model with a novel two-component speed function. In the feature extraction step, a new set of features based on peripheral information of the lesion are introduced. For this end, the peripheral area of the lesion is mapped to log-polar space using the Daugman's transformation and then a set of texture features are extracted from it. Newly introduced features do not need further segmentation of dermoscopic structures and are robust against lesion's scale, orientation, location, and shape variation. We also design the other global texture features to describe only the information from the lesion area. In the classification step, we evaluated two different schemes to prove the distinction power of the new features, one comprises linear SVM to recognize melanoma vs. nevus and the other scheme uses RUSBoost classifier to recognize melanoma vs. nevus and atypical-nevus. Sequential feature selection algorithm has been utilized in each classification scheme to rank features based on their distinction power. RESULTS: Cross-validation experiments on the well-known PH2 dataset resulted in an average of 97% for sensitivity and 100% for specificity on melanoma vs. nevus recognition task using only four features. Also, in the second classification scheme, we achieved high sensitivity and specificity values of 95% for melanoma vs. nevus and atypical nevus recognition experiments. CONCLUSION: High values for evaluation metrics show that the proposed melanoma recognition system is superior to the other state-of-the-art algorithms, which proves the high distinction power of the newly introduced features.