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2.
Euro Surveill ; 20(28)2015 Jul 16.
Artigo em Inglês | MEDLINE | ID: mdl-26212141

RESUMO

A novel GII.17 norovirus has emerged as a major cause of epidemic and endemic acute gastroenteritis in several countries in Asia. We used a small panel of stool samples in which GII.17 virus had been quantified by real-time RT-PCR to evaluate four commercially available norovirus immunochromatography (IC) kits. At least 10(8) copies/mL of GII.17 virus were required by each IC kit for a positive result, which is 1,000-fold more than that reported for these assays for GII.4 viruses.


Assuntos
Infecções por Caliciviridae/diagnóstico , Cromatografia de Afinidade/métodos , Técnicas de Laboratório Clínico/métodos , Fezes/virologia , Gastroenterite/virologia , Norovirus/isolamento & purificação , Adolescente , Adulto , Infecções por Caliciviridae/virologia , Criança , Pré-Escolar , Feminino , Gastroenterite/diagnóstico , Humanos , Lactente , Masculino , Norovirus/classificação , Norovirus/genética , Kit de Reagentes para Diagnóstico , Reação em Cadeia da Polimerase Via Transcriptase Reversa/métodos , Sensibilidade e Especificidade , Adulto Jovem
3.
Perfusion ; 30(7): 572-9, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25837980

RESUMO

OBJECTIVE: The aim of this study was to compare the biocompatibility of a new Senko E-Ternal coating (SEC) for cardiopulmonary bypass (CPB) circuits with the well-established poly-2-methoxyethyl acrylate (PMEA) coating. METHODS: Forty patients undergoing aortic valve replacement were randomly assigned to either an SEC-coated group (n = 20) or a PMEA-coated group (n = 20). Clinical data and the following markers were analyzed: platelet count, platelet factor (PF) 4, fibrinogen, fibrinogen degradation products (FDPs), antithrombin III (AT III), thrombin-antithrombin complex (TAT), plasminogen, complement hemolytic activity (CH50), complement 3 (C3) and interleukin-6 (IL-6). Blood samples were obtained at five time points in both groups. RESULTS: CPB time, aortic cross-clamp time and blood loss and transfusion were similar in both groups. There were no significant differences between the groups in terms of platelet count, PF4 and all coagulation and fibrinolytic parameters (FDP, AT III, TAT, and plasminogen) at any time points. Inflammatory markers (CH50, C3 and IL-6) were also similar in both groups at all time points. CONCLUSIONS: The SEC-coated circuit demonstrated equivalent biocompatibility to the PMEA-coated circuit. SEC-coated circuits are, therefore, favorably comparable to PMEA-coated circuits for clinical use in CPB.


Assuntos
Ponte Cardiopulmonar/instrumentação , Materiais Revestidos Biocompatíveis , Teste de Materiais/métodos , Acrilatos , Idoso , Idoso de 80 Anos ou mais , Biomarcadores/sangue , Proteínas Sanguíneas/metabolismo , Feminino , Humanos , Masculino , Polímeros
4.
Br J Anaesth ; 108(3): 512-6, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22201182

RESUMO

BACKGROUND: We have developed a new bronchoscopy system with two independent lenses at the tip of the device. This enables measurement of object size using the principle of triangulation. This study was performed to assess the accuracy of this system. METHODS: The accuracy of the bronchoscopy system was confirmed by measuring the diameters of four plastic tubes and 36 airway calibres in 12 surgical patients under general anaesthesia. The measured diameters of the tubes and airway tracts were compared with the manufactured diameters of tubes and those measured by high-resolution computed tomography (HRCT)-based virtual bronchoscopy, respectively. RESULTS: Using the new bronchoscope system, tube diameters, 9, 12, 15, and 19 mm, were measured as 9.9 (0.7), 12.8 (1.4), 16.3 (1.6), and 20.1 (2.0) mm, respectively. Airway calibres obtained by a stereovision bronchoscopy and HRCT-based virtual bronchoscopy were 8.66 (4.31) and 9.38 (5.09) mm, respectively. There is a significant correlation between airway calibres with the two measurement methods (r=0.975, P<0.01). CONCLUSIONS: We have confirmed that this new bronchoscopy system could provide relatively accurate quantitative data. This new system may be useful in the clinic to measure airway dimension and lesion sizes such as tumours.


Assuntos
Obstrução das Vias Respiratórias/diagnóstico , Broncoscópios , Broncoscopia/métodos , Tecnologia de Fibra Óptica/instrumentação , Idoso , Idoso de 80 Anos ou mais , Manuseio das Vias Aéreas/instrumentação , Manuseio das Vias Aéreas/métodos , Obstrução das Vias Respiratórias/diagnóstico por imagem , Anestesia Geral , Broncoscopia/instrumentação , Desenho de Equipamento , Feminino , Tecnologia de Fibra Óptica/métodos , Humanos , Cuidados Intraoperatórios/instrumentação , Cuidados Intraoperatórios/métodos , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X
5.
Genet Mol Res ; 8(2): 477-81, 2009 Apr 28.
Artigo em Inglês | MEDLINE | ID: mdl-19551634

RESUMO

The ethnic composition of the Brazilian population favors high frequencies of the -alpha3.7 deletion, responsible for alpha-thalassemia, because this mutation is very common in African populations. In spite of its importance, this hemoglobinopathy has been poorly investigated in Brazil, especially at the molecular level. We investigated the prevalence of the -alpha3.7 mutation in 220 individuals attended at the Municipal Hospital of Santarém, in the state of Pará. These patients were distributed into three different groups: i) 103 individuals with anemia who had microcytosis and hypochromia, ii) 11 individuals without anemia who had microcytosis and hypochromia, and iii) 106 individuals with no hematological alterations. We examined the usefulness of investigating alpha-thalassemia carrier status for microcytosis. Among the 103 patients with anemia, 20 (19.4%) were heterozygotes (-alpha3.7/alphaalpha) and one (1.0%) was a homozygote (-alpha3.7/-alpha3.7). Among the 11 patients without anemia, one heterozygote (-alpha3.7/alphaalpha) was identified; in the third group, composed of normal individuals (106 samples), deletion -alpha3.7 was found in seven samples (6.6%), all of which were heterozygotes (-alpha/alphaalpha).These frequencies are within the expected range, given available data on the distribution of this hemoglobin disorder in human populations and the ethnic composition of the population of Santarém. We found that alpha-thalassemia is a common cause of microcytosis, given that a high proportion (19.2%) of the microcytic population carried alpha-globin gene deletions.


Assuntos
alfa-Globinas/genética , Talassemia alfa/genética , Brasil , Análise Mutacional de DNA , Deleção de Genes , Heterozigoto , Humanos , Talassemia alfa/patologia
6.
Kyobu Geka ; 62(1): 36-40, 2009 Jan.
Artigo em Japonês | MEDLINE | ID: mdl-19195184

RESUMO

Coronary artery bypass grafting (CABG) is one of the options for treating acute myocardial infarction (AMI). However, the mortality of conventional CABG is reported to be high. Therefore, we assessed the outcomes of off-pump coronary artery bypass grafting (OPCAB) in patients with AMI. Between September 2004 and October 2007, 50 patients with AMI, mean age 71.7 years, were operated on. Anterior, inferior and lateral infarctions were observed in 30, 16 and 4 patients, respectively. The time from AMI to operation was <24 hours in 13 patients, <3 days in 5, <7 days in 9, <14 days in 10 and >14 days in 13. Intra-aortic balloon pumping was used in 44% of the patients. Mean number of anastomoses per patient was 4.0. There was no in-hospital mortality. Low output syndrome was observed in 1 patient, and stroke in 2. Ejection fraction of the left ventricle significantly improved after the operation (p<0.01). The graft patency rate was 97.3%. Actuarial survival was 95.9% at 3.5 years. We concluded that OPCAB is a safe and effective procedure with favorable early and midterm survival outcomes in patients with AMI.


Assuntos
Ponte de Artéria Coronária sem Circulação Extracorpórea , Infarto do Miocárdio/cirurgia , Idoso , Feminino , Humanos , Masculino , Resultado do Tratamento
7.
Acta Neurochir (Wien) ; 148(5): 535-40; discussion 540, 2006 May.
Artigo em Inglês | MEDLINE | ID: mdl-16467959

RESUMO

BACKGROUND: Several factors influencing bone graft infection after delayed cranioplasty are analyzed in order to reduce the occurrence of infection. METHODS: For about 10 years, from March 1995 to February 2005, delayed cranioplasty was performed for 206 cases. The cases comprised 124 males and 82 females. Age distribution of the patients ranged from 6 months to 79 years old. The mean postoperative follow-up period was 1834 days. Autogenous bone, which was preserved in 100% ethanol at -20 degrees C and autoclaved before operation, was used in 54 patients. Polymethylmethacrylate (PMMA) was used in 55 patients. Custom-made PMMA was used in 3 patients. Custom-made titanium mesh was used in 77 patients. Custom-made ceramics (Alumina-ceramics 10 cases and hydroxyapatite 7 cases) was used in 17 patients. FINDINGS: Autoclaved and autogenous bone graft and PMMA have a significantly high rate of graft infection. Titanium mesh has the significantly lowest rate of graft infection. Alumina-ceramic has a merit that it has sufficient strength, however the number of cases using custom-made ceramics including alumina-ceramic was relatively small, and thus we cannot find significant differences in infection rate compared with that of other materials. There was no statistically significant difference in the bone graft infection rate among four categories of preceding diseases; cerebrovascular diseases, head trauma, infectious diseases, and brain tumour. CONCLUSION: Autoclaved and autogenous bone grafts and PMMA have a significantly higher rate of graft infection. Titanium mesh has the significantly lowest rate of graft infection.


Assuntos
Doenças Ósseas Infecciosas/etiologia , Substitutos Ósseos/efeitos adversos , Transplante Ósseo/efeitos adversos , Procedimentos de Cirurgia Plástica/efeitos adversos , Infecções Relacionadas à Prótese/etiologia , Crânio/cirurgia , Adolescente , Adulto , Idoso , Cerâmica/efeitos adversos , Criança , Pré-Escolar , Feminino , Seguimentos , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Polimetil Metacrilato/efeitos adversos , Fatores de Risco , Titânio/efeitos adversos
8.
Kyobu Geka ; 55(8 Suppl): 688-92, 2002 Jul.
Artigo em Japonês | MEDLINE | ID: mdl-12174659

RESUMO

We report 2 cases of aortic disease with Marfan syndrome underwent surgery. Case 1 was 38-years-old man and case 2 was 36-years-old woman. They were brothers and they had 8 times operation for 13 years. Surgical procedure included aortic root reconstruction, descending aortic aneurysm repair and abdominal aortic aneurysm repair. Patients with Marfan syndrome sometimes require repeated surgical repair of aortic disease.


Assuntos
Síndrome de Marfan/cirurgia , Adulto , Dissecção Aórtica/cirurgia , Aorta/cirurgia , Aneurisma Aórtico/cirurgia , Insuficiência da Valva Aórtica/cirurgia , Implante de Prótese Vascular , Feminino , Humanos , Masculino , Núcleo Familiar , Reoperação
9.
Neuroreport ; 12(17): 3755-8, 2001 Dec 04.
Artigo em Inglês | MEDLINE | ID: mdl-11726788

RESUMO

Galectin-9 is an eosinophil chemoattractant produced by activated T lymphocytes. We have addressed expression of galectin-9 in normal human astrocytes in culture. Expression of galectin-9 mRNA and protein were examined by reverse transcription-polymerase chain reaction (RT-PCR), Western blotting, and immunofluorescent staining. Interleukin-1beta (IL-1beta) was found to enhance the galectin-9 expression in time- and concentration-dependent manners. Galectin-9 protein was detected in the membrane fraction, 105 000 x g precipitate, and immunofluorescent staining revealed diffuse cellular and perinuclear distributions. Dexamethasone pretreatment almost completely suppressed the production. We conclude that astrocytes produce galectin-9 in response to the stimulation with IL-1beta, and this may contribute to inflammatory reactions in the CNS.


Assuntos
Astrócitos/imunologia , Encéfalo/imunologia , Encefalite/imunologia , Galectinas , Regulação da Expressão Gênica/fisiologia , Interleucina-1/farmacologia , Lectinas/imunologia , Anti-Inflamatórios/farmacologia , Astrócitos/citologia , Astrócitos/efeitos dos fármacos , Encéfalo/citologia , Encéfalo/efeitos dos fármacos , Compartimento Celular/efeitos dos fármacos , Compartimento Celular/imunologia , Células Cultivadas , Dexametasona/farmacologia , Relação Dose-Resposta a Droga , Encefalite/genética , Encefalite/metabolismo , Imunofluorescência , Regulação da Expressão Gênica/efeitos dos fármacos , Humanos , Interleucina-1/imunologia , Membranas Intracelulares/efeitos dos fármacos , Membranas Intracelulares/metabolismo , Lectinas/genética , Lectinas/metabolismo , RNA Mensageiro/efeitos dos fármacos , RNA Mensageiro/metabolismo , Regulação para Cima/efeitos dos fármacos , Regulação para Cima/imunologia
10.
Am J Respir Cell Mol Biol ; 25(2): 233-8, 2001 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-11509334

RESUMO

Bronchial epithelial cells may contribute to airway inflammation by releasing chemokines and expressing surface membrane molecules involved in the adhesion of leukocytes. We found that interferon (IFN)-gamma stimulates expression of fractalkine, a potent chemoattractant for monocytes and T lymphocytes, in a time- and concentration-dependent manner by normal human bronchial epithelial cells in culture. Enhanced expression of fractalkine messenger RNA was confirmed by both reverse transcription/polymerase chain reaction and Northern blotting. IFN-gamma also stimulated fractalkine protein production and most of the protein was found in cell lysates. The adherence of blood mononuclear cells to the monolayers of bronchial epithelial cells stimulated with IFN-gamma was partly inhibited by an antifractalkine antibody. An antibody against intercellular adhesion molecule-1 was similarly effective in inhibiting the adhesion. Fractalkine protein levels in bronchoalveolar lavage fluids from patients with inflammatory diseases correlated positively with mononuclear cell counts in the fluids. The bronchial epithelium in a biopsy specimen of lung cancer was stained positively by immunofluorescent staining for fractalkine. We conclude that IFN-gamma stimulates fractalkine expression by bronchial epithelial cells, which may play an important role in inflammatory responses by recruiting mononuclear leukocytes to the bronchial epithelium.


Assuntos
Brônquios/efeitos dos fármacos , Brônquios/metabolismo , Quimiocinas CX3C/genética , Interferon gama/farmacologia , Leucócitos Mononucleares/efeitos dos fármacos , Proteínas de Membrana/genética , Sequência de Bases , Líquido da Lavagem Broncoalveolar/química , Adesão Celular/efeitos dos fármacos , Células Cultivadas , Quimiocina CX3CL1 , Quimiocinas CX3C/metabolismo , Primers do DNA/genética , Células Epiteliais/efeitos dos fármacos , Células Epiteliais/metabolismo , Imunofluorescência , Expressão Gênica/efeitos dos fármacos , Humanos , Leucócitos Mononucleares/citologia , Proteínas de Membrana/metabolismo , RNA Mensageiro/genética , RNA Mensageiro/metabolismo
12.
Cancer ; 91(5): 964-71, 2001 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-11251948

RESUMO

BACKGROUND: Transforming growth factor-beta1 (TGF- beta1) is a multifunctional factor and is known to affect tumor growth in malignant tumors. The effects of TGF-beta1 on angiogenesis, stromal formation, and immune function suggest its possible involvement in tumor progression. The authors examined whether TGF-beta1 levels may be correlated with angiogenesis, clinicopathologic factors, and survival in patients with surgically resected lung carcinoma. METHODS: TGF-beta1 protein was extracted from 53 nonsmall cell lung carcinoma tissue samples (19 squamous cell carcinomas, 33 adenocarcinomas, and 1 adenosquamous cell carcinoma), and its level was measured by enzyme-linked immunosorbent assay. To assess tumor angiogenesis, microvessel density (MVD) was determined by CD31 immunostaining. RESULTS: The protein level of TGF-beta1 was 289 picograms per milligram of protein (pg/mg protein), ranging from 94 pg/mg protein to 584 pg/mg protein. The TGF-beta1 protein level was significantly higher in patients with lymph node metastasis compared with patients who were without lymph node metastasis (P = 0.02), and the TGF-beta1 protein level was significantly higher in patients with Stage III disease (TNM classification) compared with patients who had Stage I and II disease (P = 0.03). There was no significant correlation between the TGF-beta1 protein level and any of the other clinicopathologic factors that were considered. A significant positive correlation between TGF-beta1 protein level and MVD was noted (P < 0.01). Furthermore, in patients with adenocarcinoma, a significant correlation between TGF-beta1 protein level and prognosis was detected by multivariate analysis (P = 0.028). CONCLUSIONS: TGF-beta1 seems to affect tumor angiogenesis and to play an important role in tumor progression in patients with nonsmall cell lung carcinoma. Furthermore, the TGF-beta1 protein level may be an independent predictor of survival in patients with adenocarcinoma of the lung.


Assuntos
Carcinoma Pulmonar de Células não Pequenas/patologia , Neoplasias Pulmonares/patologia , Neovascularização Patológica , Fator de Crescimento Transformador beta/análise , Adulto , Idoso , Carcinoma Pulmonar de Células não Pequenas/irrigação sanguínea , Carcinoma Pulmonar de Células não Pequenas/cirurgia , Progressão da Doença , Feminino , Humanos , Neoplasias Pulmonares/irrigação sanguínea , Neoplasias Pulmonares/cirurgia , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Prognóstico , Estudos Prospectivos , Análise de Regressão , Fator de Crescimento Transformador beta/farmacologia
13.
Jpn J Thorac Cardiovasc Surg ; 49(2): 113-6, 2001 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-11257766

RESUMO

OBJECTIVE: We determined the efficacy of surgery for acute pulmonary thromboembolism with a floating right-heart thrombus. METHODS AND RESULTS: Thrombi were diagnosed by transthoracic echocardiography and electron beam computed tomography in 4 patients with acute pulmonary thromboembolism with a floating right-heart thrombus, and thromboembolectomy was done in all patients. Surgical procedure included intermittent deep hypothermic circulatory arrest. One patient died of endobronchial hemorrhage and 3 survived. CONCLUSION: Because acute pulmonary thromboembolism with a right-heart thrombus is life-threatening, immediate thromboembolectomy is required to decrease mortality.


Assuntos
Cardiopatias/cirurgia , Embolia Pulmonar/cirurgia , Trombose/cirurgia , Doença Aguda , Adulto , Idoso , Ecocardiografia , Feminino , Cardiopatias/complicações , Cardiopatias/diagnóstico por imagem , Humanos , Masculino , Pessoa de Meia-Idade , Embolia Pulmonar/complicações , Embolia Pulmonar/diagnóstico por imagem , Trombectomia , Trombose/complicações , Trombose/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Resultado do Tratamento
14.
Kyobu Geka ; 53(1): 60-3, 2000 Jan.
Artigo em Japonês | MEDLINE | ID: mdl-10639795

RESUMO

We report a case of left ventricular rupture and left ventricular-right atrial communication after mitral valve re-replacement. A 53-year-old man was admitted to our hospital for a primary tissue failure of mitral xenograft. On June 4, 1997, he underwent mitral valve re-replacement. At 12 post operative day, he was suffered from unexpected dyspnea. The transesophageal echocardiography showed floated mitral valve and left ventricular-right atrial communication. The emergent operation was done. At the operation, posterior mitral annulus was disrupted and the disruption reached to a membranous septum. A communication was directly closed, mitral annulus was repaired with perigard and one size smaller mitral valve was implanted. The patient was discharged and returned to social life.


Assuntos
Fístula/etiologia , Implante de Prótese de Valva Cardíaca/efeitos adversos , Valva Mitral/cirurgia , Ruptura do Septo Ventricular/etiologia , Átrios do Coração , Ventrículos do Coração , Humanos , Masculino , Pessoa de Meia-Idade , Insuficiência da Valva Mitral/cirurgia , Complicações Pós-Operatórias
15.
Eur Respir J ; 14(2): 309-14, 1999 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-10515406

RESUMO

Interleukin (IL)-10 is a potent regulatory cytokine that decreases inflammatory responses. This study investigated whether IL-10 levels in the airway are decreased in chronic airway inflammation associated with asthma or chronic obstructive pulmonary disease (COPD). Sputum was obtained from 12 healthy nonsmokers, 10 healthy smokers, 16 asthmatic patients and seven patients with COPD by means of the sputum-induction method. The IL-10 level was measured via enzyme-linked immunosorbent assay and immunocytochemical analysis. The IL-10 level in sputum was significantly lower in asthma and COPD patients and healthy smokers compared with that in healthy nonsmokers (nonsmokers, 68.0+/-11.3; smokers, 45.3+/-7.8; asthma, 26.7+/-4.0; COPD, 18.0+/-2.3 pg x mL(-1); p<0.05 for nonsmokers versus the other groups). The percentage of IL-10-positive cells in the sputum was also significantly lower in asthma and COPD and in smokers (nonsmokers, 13.2+/-1.7; smokers, 6.4+/-1.8; asthma, 5.4+/-3.5; COPD, 3.5+/-1.6%; p<0.05 for nonsmokers versus the other groups). The IL-10-positive cell appeared morphologically to be the macrophage. These data suggest that the reduced level of interleukin-10 within the airways plays a role in the pathogenesis of chronic airway inflammation in asthma and chronic obstructive pulmonary disease.


Assuntos
Asma/imunologia , Interleucina-10/metabolismo , Pneumopatias Obstrutivas/imunologia , Fumar/imunologia , Escarro/imunologia , Adulto , Idoso , Asma/diagnóstico , Ensaio de Imunoadsorção Enzimática , Feminino , Volume Expiratório Forçado/fisiologia , Humanos , Técnicas Imunoenzimáticas , Pneumopatias Obstrutivas/diagnóstico , Masculino , Pessoa de Meia-Idade , Valores de Referência , Fumar/efeitos adversos
16.
J Clin Lab Immunol ; 51(1): 39-53, 1999.
Artigo em Inglês | MEDLINE | ID: mdl-11424740

RESUMO

We investigated the effect of a potent synthetic steroid, budesonide (BUD), on the survival of nasal polyp (NP) derived eosinophils (EOS). BUD, at the highest dose used, 10(-6) M, decreased this survival but only by approximately one third. We speculated that the relatively small inhibitory effect of budesonide on the survival of NP-EOS could be the result of these EOS being exposed to substantial amounts of GM-CSF, IL-5 or IL-3. In this regard, we detected 148 pg of GM-CSF per 150 mg of tissue, which approximately contained 106 of eosinophils, in the supernatant of NP explants for 24 h without any stimulation. Contents of both IL-5 and IL-3 were much less. We further studied survival of PB-EOS exposed to rhGM-CSF and found that 10(-6) M of BUD could only inhibit by less than one third the survival of PB-EOS exposed to an amount of rhGM-CSF, similar to that detected in the supernatant of NP explants. In addition, we exposed PB-EOS to 200 pg/ml of rhGM-CSF for a relatively long period of time (4 days) in order to mimic chronic exposure in the tissue and found that the survival of these cells was prolonged to the extent similar to that observed in NP-EOS. Our data suggests that the prolonged spontaneous survival of NP-EOS ex vivo is likely the result of sustained in vivo exposure to GM-CSF and budesonide has a smaller inhibitory effect in the survival of these eosinophils as compared to those from peripheral blood.


Assuntos
Budesonida/farmacologia , Eosinófilos/efeitos dos fármacos , Pólipos Nasais/patologia , Administração Tópica , Anti-Inflamatórios/administração & dosagem , Anti-Inflamatórios/farmacologia , Budesonida/administração & dosagem , Sobrevivência Celular/efeitos dos fármacos , Citocinas/metabolismo , Interações Medicamentosas , Eosinófilos/citologia , Eosinófilos/fisiologia , Glucocorticoides , Fator Estimulador de Colônias de Granulócitos e Macrófagos/administração & dosagem , Fator Estimulador de Colônias de Granulócitos e Macrófagos/metabolismo , Fator Estimulador de Colônias de Granulócitos e Macrófagos/farmacologia , Humanos , Técnicas In Vitro , Pólipos Nasais/fisiopatologia , Proteínas Recombinantes/administração & dosagem , Proteínas Recombinantes/farmacologia
17.
Kyobu Geka ; 50(5): 413-6, 1997 May.
Artigo em Japonês | MEDLINE | ID: mdl-9136541

RESUMO

A case of primary and malignant melanoma of the esophagus was reported. A 64-year-old male complaining of discomfort of anterior chest pain was admitted to our hospital for operation. Findings of upper G-1 X-ray and endoscopic examination revealed suspiciously malignant melanoma. Subtotal thoracic esophagectomy with R III dissection was performed. Operative findings included A0 N2 Pl0 M0 Stage III. Macroscopically it showed black-grayish colored polypoid tumors, 7 cm in size. The typical finding of junctional activity adjacent to the tumor mass and melanocytes were microscopically found. The patient received postoperative systemic chemotherapy, but was died of multiple liver and bone metastases 125 days after surgery. Malignant melanoma of the esophagus has extremely poor prognosis and none of effective therapies has been reported.


Assuntos
Neoplasias Esofágicas/cirurgia , Melanoma/cirurgia , Neoplasias Esofágicas/patologia , Humanos , Masculino , Melanoma/patologia , Pessoa de Meia-Idade , Prognóstico
18.
Nihon Kyobu Geka Gakkai Zasshi ; 45(4): 645-8, 1997 Apr.
Artigo em Japonês | MEDLINE | ID: mdl-9155142

RESUMO

A 43-year-old male presented with a history of occasional syncopal episodes and general fatigue for 4 months. On admission, a grade 4/6 systolic murmur was noted, and the electrocardiogram demonstrated frequent premature supraventricular beats. An echocardiogram revealed the presence of a multi-lobular mass in the right ventricle which prolapsed into the pulmonary artery during systole. Ultrafast computed tomography demonstrated a pedunculated mass arising from the right ventricular free well. At operation, the soft mass was excised through the tricuspid valve under cardiac arrest. Histopathologically, the tumor was diagnosed as a myxoma. Myxoma of the right ventricle occurs very rare. We review the literature relevant to cardiac myxoma.


Assuntos
Neoplasias Cardíacas/cirurgia , Mixoma/cirurgia , Adulto , Ventrículos do Coração , Humanos , Masculino
19.
Nihon Kyobu Geka Gakkai Zasshi ; 44(9): 1796-9, 1996 Sep.
Artigo em Japonês | MEDLINE | ID: mdl-8911059

RESUMO

A 68-year-old female has developed dyspnea on effort for 5 years. On admission, a grade 2/6 apical systolic regurgitant murmur was noted. Chest X-ray examination showed moderate cardiac enlargement. Echocardiogram showed a highly echoic mass with acoustic shadow in the left atrium which was attached to the interatrial septum. A partial herniation of the tumor through the mitral annulus in diastolic phase and moderate mitral regurgitation was noted. Ultra fast computed tomography of the chest revealed a left atrial mass with high density area. At operation the mass was excised with atrial septum through the right atriotomy. Microscopic findings showed the myxoma with bone and bone marrow formation.


Assuntos
Neoplasias Cardíacas/cirurgia , Mixoma/cirurgia , Ossificação Heterotópica/complicações , Idoso , Feminino , Átrios do Coração , Neoplasias Cardíacas/complicações , Humanos , Insuficiência da Valva Mitral/complicações , Mixoma/complicações
20.
Nihon Kyobu Shikkan Gakkai Zasshi ; 34(7): 747-54, 1996 Jul.
Artigo em Japonês | MEDLINE | ID: mdl-8810754

RESUMO

To study pathophysiologic phenomena in acute pulmonary embolism, we injected sephadex G-75 (SG-75) into rabbit auricular veins and measured the changes in blood gases and in platelet aggregability. Severe hypoxemia developed within 10 minutes of SG-75 injection. Microscopic examination of samples taken 120 minutes after SG-75 injection pulmonary artery had been embolized by the SG-75 particles, and that thrombin had formed around the particles. The lowest platelet counts were measured 10 minutes after SG-75 injection. The rates of platelet aggregation induced by adenosine diphosphate and by platelet-activating factor were abnormally low until 40 minutes after SG-75 injection. These results suggest that platelets were activated by anoxia and that the activated platelets moved around the emboli after obstruction of the pulmonary artery. We conclude that decreases in PaO2 and changes in platelet aggregability exacerbate the pathophysiologic processes in acute pulmonary embolism.


Assuntos
Dióxido de Carbono/sangue , Oxigênio/sangue , Agregação Plaquetária , Embolia Pulmonar/sangue , Reação de Fase Aguda , Difosfato de Adenosina/farmacologia , Animais , Gasometria , Dextranos , Modelos Animais de Doenças , Masculino , Fator de Ativação de Plaquetas/farmacologia , Agregação Plaquetária/efeitos dos fármacos , Contagem de Plaquetas , Embolia Pulmonar/induzido quimicamente , Embolia Pulmonar/patologia , Coelhos
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