Assuntos
Morfinanos/administração & dosagem , Morfinanos/farmacologia , Prurido/tratamento farmacológico , Prurido/etiologia , Diálise Renal/efeitos adversos , Compostos de Espiro/administração & dosagem , Compostos de Espiro/farmacologia , Uremia/complicações , Administração Oral , Animais , Cápsulas , Ensaios Clínicos como Assunto , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Humanos , Morfinanos/metabolismo , Morfinanos/farmacocinética , Receptores Opioides/agonistas , Receptores Opioides/metabolismo , Compostos de Espiro/metabolismo , Compostos de Espiro/farmacocinéticaRESUMO
The chemical constituents of the root extracts and the nucleotide sequences of the atpB-rbcL intergenic region of Ligularia latihastata and L. villosa, collected in northwestern Yunnan Province, were studied. In the twelve collected samples of L. latihastata, two major benzofurans, 5,6-dimethoxy-2-(1-methylethenyl)-1-benzofuran (1) and euparin (2) were detected as major components. The minor compound (2R*,3S*)-5-acetyl-2,3-dihydro-6-hydroxy-2-(1-methylethenyl)-1-benzofuran-3-yl (2Z)-2-[(acetoxy)methyl]but-2-enoate (4) was found to be susceptible to artifact formation upon extraction with EtOH. The intra-specific diversity in chemical composition of the samples was small, but the diversity in the atpB-rbcL sequence was fairly large. Compounds 1 and 2 were also found in the three collected samples of L. villosa, indicating that the two species are chemically close to each other, in agreement with morphological taxonomy.
