Dos inhibidores de recaptación de serotonina en eyaculación precoz / 2 serotonin reuptake inhibitors in premature ejaculation

La eyaculación precoz es muy frecuente, pero sólo consultan aquellos hombres que lo sienten como problema. Los inhibidores de la recaptacción de Serotonina actuan a nivel de la vesícula sináptica impidiendo la recaptación del neurotransmisor, permitiendo así una mayor utilización por la neurona sináptica

The heterogeneity of the age-related decline in immune response: impairment in delayed-type hypersensitivity and cytotoxic T-lymphocyte activity occur independently.

Aged mice are known to have a heterogeneous cytotoxic T-lymphocyte (CTL) response to an influenza challenge. We sought to determine whether delayed-type hypersensitivity (DTH) to sheep red blood cells (SRBC) was also heterogeneous in aging and, if so, whether this correlated with anti-influenza CTL activity. Aged mice developed mean footpad swelling of 0.24 +/- 0.09 mm following SRBC challenge and mean CTL activity of 35 +/- 18%. Even though these values were significantly lower than those from young mice (0.54 +/- 0.10 mm and 51 +/- 2%, respectively), no correlation was found between anti-influenza CTL activity and DTH to SRBC (r = 0.01). We believe the most likely reason for this independent decline in immune response is because different activation signals are required for DTH and CTL activity. Our data thus suggest an age-related functional mosaicism in the immune system.

Enhancement of anti-influenza cytotoxic T-lymphocyte activity in senescent mice by vaccination early in life.

The elderly suffer significantly from influenza and respond poorly to influenza vaccines. This may be due to the fact that cytotoxic T-lymphocyte (CTL) activity is responsible for recovery from viral infections and is decreased in the elderly. We hypothesized that vaccination early in life might increase activity in senescence. To test this, groups of BALB/c mice were infected with influenza virus and/or vaccinated with an inactivated vaccine. CTL activity was measured by 51Cr release from H1N1-infected P815 cells. We found that aged mice have low CTL activity when initially vaccinated at 22 months (4 +/- 4% vs. 23 +/- 6% for vaccinated young mice). However, CTL activity was significantly increased when animals were initially vaccinated when young and then re-vaccinated when old (28 +/- 10% vs. 13 +/- 17% for mice vaccinated twice in old age). We next measured CTL activity in response to infection. We found a very high level of activity (57 +/- 11%) in animals vaccinated at 1.5 months and then infected at 23 months. This was indistinguishable from young controls (56 +/- 7%). These data suggest that primary inoculation at an early age induces a relatively larger number of precursor CTLs than does inoculation in senescence.