RESUMO
The use of a series of liquid chromatographic techniques involving cation-exchange, reverse-phase and normal-phase chromatography has permitted the separation and characterisation of a number of metabolites of the psychotomimetic indolealkylamines N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine which were isolated following incubation of these compounds with rat tissue extracts. In liver, kidney and brain tissue extracts the routes of metabolism identified included oxidative deamination, N-demethylation, O-demethylation and N-oxidation. The quantitative significance of individual routes of metabolism in these tissues was assessed using N,N-dimethyltryptamine as a substrate.
Assuntos
Encéfalo/metabolismo , Rim/metabolismo , Fígado/metabolismo , Metoxidimetiltriptaminas/metabolismo , N,N-Dimetiltriptamina/metabolismo , Psicometria , Serotonina/análogos & derivados , Triptaminas/metabolismo , Animais , Cromatografia Líquida de Alta Pressão/métodos , Citosol/metabolismo , Masculino , Microssomos/metabolismo , N,N-Dimetiltriptamina/análogos & derivados , Ratos , Ratos EndogâmicosRESUMO
Following intraperitoneal administration, 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine are subject to both a very rapid uptake into, and clearance from, all tissues examined. The current studies in vivo confirm previous in vitro observations that the routes involved in the metabolism of these compounds include oxidative deamination, N-demethylation, O-demethylation, and N-oxidation. The analysis of metabolic profiles in various tissues led to the identification of the N-oxides as major metabolites. The successful inhibition and redirection of metabolism away from the indole acids towards the parent compounds and their structurally unique metabolites were demonstrated in animals pretreated with iproniazid.