1.
2.
Acta Derm Venereol
; 94(3): 319-20, 2014 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24002114
Assuntos
Antimetabólitos Antineoplásicos/administração & dosagem , Linfoma Anaplásico de Células Grandes/tratamento farmacológico , Metotrexato/administração & dosagem , Neoplasias Cutâneas/tratamento farmacológico , Idoso , Biomarcadores Tumorais/análise , Biópsia , Feminino , Humanos , Imuno-Histoquímica , Injeções Intralesionais , Linfoma Anaplásico de Células Grandes/química , Linfoma Anaplásico de Células Grandes/imunologia , Linfoma Anaplásico de Células Grandes/patologia , Neoplasias Cutâneas/química , Neoplasias Cutâneas/imunologia , Neoplasias Cutâneas/patologia , Resultado do Tratamento
3.
Science
; 314(5801): 985-9, 2006 Nov 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17095701
RESUMO
Some pathogenic bacteria actually invade the cytoplasm of their target host cells. Invasive bacteria acquire the propulsive force to move by recruiting actin and inducing its polymerization. Here we show that Shigella movement within the cytoplasm was severely hindered by microtubules and that the bacteria destroyed surrounding microtubules by secreting VirA by means of the type III secretion system. Degradation of microtubules by VirA was dependent on its alpha-tubulin-specific cysteine protease-like activity. virA mutants did not move within the host cytoplasm and failed to move into adjacent cells.