RESUMO
A 64-year-old man had a sudden onset of gastrointestinal bleeding. He had been diagnosed as systemic mantle cell lymphoma (MCL) 27 months ago, and the first-line chemotherapy was undergone. After maintaining CR state during 12 months, he showed PD. Upper gastrointestinal endoscopy revealed multiple lymphomatous polyps, and active bleeding was noticed from the ulceration of the top of these polyps. After hemostasis was gained, biopsies were done twice and a local recurrence of MCL was diagnosed finally by immunohistological examination. In consequence of the second-line chemotherapy including bendamustine, he was introduced into CR again. We present this rare case of long-term follow up of MCL with a series of upper gastrointestinal endoscopy.