RESUMO
HLA-B*15:679 and HLA-C*15:02:01:61 differ from HLA-B*15:12:01 and HLA-C*15:02:01:01 by a single nucleotides.
Assuntos
Alelos , Sequência de Bases , Antígenos HLA-C , Teste de Histocompatibilidade , Humanos , Antígenos HLA-C/genética , Índia , Éxons , Análise de Sequência de DNA/métodos , Polimorfismo de Nucleotídeo Único , Antígeno HLA-B15/genética , Antígeno HLA-B15/imunologia , Alinhamento de Sequência , CódonRESUMO
Allele variants HLA-C*01:02:01:74Q and -C*15:02:01:63 differ from -C*01:02:01:01 and -15:02:01:01 by a single nucleotide, respectively.
Assuntos
Alelos , Antígenos HLA-C , Teste de Histocompatibilidade , Humanos , Antígenos HLA-C/genética , Polimorfismo de Nucleotídeo Único , Éxons , Índia , Sequência de Bases , Análise de Sequência de DNA/métodosRESUMO
Novel HLA-C*06:02:01:94 and -C*15:02:01:58 alleles were detected during the routine HLA typing process.
RESUMO
The novel HLA-B*15:665 and HLA-C*12:02:02:23 alleles were detected during the routine HLA typing process.
RESUMO
The novel HLA-A*01:01:01:111 allele was detected during routine HLA typing.
Assuntos
Antígenos HLA-A , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Alelos , Índia , Teste de Histocompatibilidade , Antígenos HLA-A/genéticaRESUMO
Relationship between various combinations of KIR ligands and HLA alleles have been studied in several diseases. The aim of this retrospective study was to estimate the frequency of HLA alleles and KIR ligands among acute myeloid leukemia patients and healthy controls in order to examine the possible association of HLA alleles and KIR ligands with AML. A total of 439 acute myeloid leukemia patients and 1317 unrelated, healthy ethnic Indian controls were included in the study. HLA typing was performed using PCR-SSP. KIR ligands were assigned by using the KIR ligand Calculator. The frequency of HLA alleles and KIR ligands in patients was then compared with the controls. As compared to controls, frequencies of HLA-A*03 and HLA-B*35 were increased in AML patients, whereas, that of HLA-C*03 was decreased. Frequencies of HLA-A*03 and HLA-C*15 were increased in male patients, however, no significant difference was observed in female patients as compared to controls. In the pediatric group, the frequencies of HLA-A*01 was decreased and that of HLA-A*03 and HLA-B*18 were increased, whereas, frequencies of HLA-B*13 was decreased and that of HLA-B*27 was increased in the adult patients. In the haplotype analysis, the frequency of HLA-A*24/B*35/DRB1*15 was increased in overall patients. In adult group, the frequency of HLA-A*01/B*44/DRB1*07 was increased in patients than in controls. No significant association was observed between KIR ligands and susceptibility/ protection to AML. Our results indicate that certain HLA alleles and haplotypes have presumptive positive or negative role in conferring protection/susceptibility to AML. Supplementary Information: The online version contains supplementary material available at 10.1007/s12288-022-01550-0.
RESUMO
The novel HLA-C*12:02:47 allele was detected during routine HLA typing.
Assuntos
Antígenos HLA-C , Humanos , Antígenos HLA-C/genética , Alelos , ÍndiaRESUMO
The novel allele HLA-B*37:01:01:19 differs from B*37:01:01:01 by one nucleotide A->G in Intron 3 at gDNA1430.
Assuntos
Antígenos HLA-B , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Alelos , Íntrons , Índia , Antígenos HLA-B/genéticaRESUMO
The novel allele HLA-C*03:599 as compared with HLA-C*03:04:01:02 displays polymorphism at position; gDNA 1618 (G>T).
Assuntos
Antígenos HLA-C , Humanos , Antígenos HLA-C/genética , AlelosRESUMO
The novel alleles HLA-DQA1*01:01:01:11 and -DQA1*01:03:01:13 were detected during the routine HLA typing process.
Assuntos
Alelos , Humanos , Cadeias alfa de HLA-DQ/genética , Índia , Teste de Histocompatibilidade , Análise de Sequência de DNARESUMO
The novel HLA-DPA1*01:03:01:64 allele was detected during routine HLA typing.
Assuntos
Cadeias alfa de HLA-DP , Humanos , Alelos , Cadeias alfa de HLA-DP/genética , Teste de Histocompatibilidade , ÍndiaRESUMO
The novel allele HLA-C*07:02:01:184 as compared with HLA-C*07:02:01:03 displays polymorphism at position; gDNA 2896 (G > C).
Assuntos
Antígenos HLA-C , Humanos , Alelos , Sequência de Bases , Genes MHC Classe I , Sequenciamento de Nucleotídeos em Larga Escala , Antígenos HLA-C/genéticaRESUMO
The novel allele, HLA-B*40:02:01:39 differs from the HLA-B*40:02:01:01 allele by a single nucleotide change at gDNA position 700.
Assuntos
Antígenos HLA-B , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Alelos , Antígenos HLA-B/genética , Genes MHC Classe I , ÍndiaRESUMO
The novel HLA-B*58:01:01:19 allele was characterized using next generation sequencing technology.
Assuntos
Genes MHC Classe I , Antígenos HLA-B , Humanos , Alelos , Antígenos HLA-B/genética , Sequenciamento de Nucleotídeos em Larga EscalaRESUMO
The novel allele HLA-C*06:02:38:02 differs from HLA-C*06:02:38:01 by a nucleotide change at position; gDNA 168 T â A.
Assuntos
Genes MHC Classe I , Antígenos HLA-C , Humanos , Antígenos HLA-C/genética , Alelos , Índia , NucleotídeosRESUMO
The novel allele HLA-A*02:11:01:06 as compared with HLA-A*02:11:01:01 displays polymorphism at position; gDNA 1562 (C>A).
Assuntos
Antígenos HLA-A , Humanos , Alelos , Antígenos HLA-A/genéticaRESUMO
The novel allele HLA-A*11:01:01:86 differs from HLA-A*11:01:01:86 by one nucleotide change at position; gDNA-32 (A- > C).
