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1.
Prog Neurobiol ; 236: 102603, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38604582

RESUMO

The STRAT-PARK initiative aims to provide a platform for stratifying Parkinson's disease (PD) into biological subtypes, using a bottom-up, multidisciplinary biomarker-based and data-driven approach. PD is a heterogeneous entity, exhibiting high interindividual clinicopathological variability. This diversity suggests that PD may encompass multiple distinct biological entities, each driven by different molecular mechanisms. Molecular stratification and identification of disease subtypes is therefore a key priority for understanding and treating PD. STRAT-PARK is a multi-center longitudinal cohort aiming to recruit a total of 2000 individuals with PD and neurologically healthy controls from Norway and Canada, for the purpose of identifying molecular disease subtypes. Clinical assessment is performed annually, whereas biosampling, imaging, and digital and neurophysiological phenotyping occur every second year. The unique feature of STRAT-PARK is the diversity of collected biological material, including muscle biopsies and platelets, tissues particularly useful for mitochondrial biomarker research. Recruitment rate is ∼150 participants per year. By March 2023, 252 participants were included, comprising 204 cases and 48 controls. STRAT-PARK is a powerful stratification initiative anticipated to become a global research resource, contributing to personalized care in PD.


Assuntos
Doença de Parkinson , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Biomarcadores , Canadá , Estudos de Coortes , Estudos Longitudinais , Noruega , Doença de Parkinson/diagnóstico , Doença de Parkinson/fisiopatologia , Medicina de Precisão/métodos
2.
Sensors (Basel) ; 20(18)2020 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-32942750

RESUMO

Insect detection and control at an early stage are essential to the built environment (human-made physical spaces such as homes, hotels, camps, hospitals, parks, pavement, food industries, etc.) and agriculture fields. Currently, such insect control measures are manual, tedious, unsafe, and time-consuming labor dependent tasks. With the recent advancements in Artificial Intelligence (AI) and the Internet of things (IoT), several maintenance tasks can be automated, which significantly improves productivity and safety. This work proposes a real-time remote insect trap monitoring system and insect detection method using IoT and Deep Learning (DL) frameworks. The remote trap monitoring system framework is constructed using IoT and the Faster RCNN (Region-based Convolutional Neural Networks) Residual neural Networks 50 (ResNet50) unified object detection framework. The Faster RCNN ResNet 50 object detection framework was trained with built environment insects and farm field insect images and deployed in IoT. The proposed system was tested in real-time using four-layer IoT with built environment insects image captured through sticky trap sheets. Further, farm field insects were tested through a separate insect image database. The experimental results proved that the proposed system could automatically identify the built environment insects and farm field insects with an average of 94% accuracy.


Assuntos
Aprendizado Profundo , Insetos , Internet das Coisas , Controle de Pragas , Animais , Redes Neurais de Computação
3.
Sensors (Basel) ; 20(12)2020 Jun 23.
Artigo em Inglês | MEDLINE | ID: mdl-32585864

RESUMO

The role of mobile robots for cleaning and sanitation purposes is increasing worldwide. Disinfection and hygiene are two integral parts of any safe indoor environment, and these factors become more critical in COVID-19-like pandemic situations. Door handles are highly sensitive contact points that are prone to be contamination. Automation of the door-handle cleaning task is not only important for ensuring safety, but also to improve efficiency. This work proposes an AI-enabled framework for automating cleaning tasks through a Human Support Robot (HSR). The overall cleaning process involves mobile base motion, door-handle detection, and control of the HSR manipulator for the completion of the cleaning tasks. The detection part exploits a deep-learning technique to classify the image space, and provides a set of coordinates for the robot. The cooperative control between the spraying and wiping is developed in the Robotic Operating System. The control module uses the information obtained from the detection module to generate a task/operational space for the robot, along with evaluating the desired position to actuate the manipulators. The complete strategy is validated through numerical simulations, and experiments on a Toyota HSR platform.


Assuntos
Betacoronavirus , Infecções por Coronavirus/prevenção & controle , Desinfecção/instrumentação , Pandemias/prevenção & controle , Pneumonia Viral/prevenção & controle , Robótica/instrumentação , Algoritmos , COVID-19 , Infecções por Coronavirus/transmissão , Infecções por Coronavirus/virologia , Aprendizado Profundo , Desinfecção/métodos , Desenho de Equipamento , Humanos , Manutenção , Movimento (Física) , Pneumonia Viral/transmissão , Pneumonia Viral/virologia , Robótica/métodos , Robótica/estatística & dados numéricos , SARS-CoV-2
4.
Sensors (Basel) ; 20(6)2020 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-32197483

RESUMO

This work presents a table cleaning and inspection method using a Human Support Robot (HSR) which can operate in a typical food court setting. The HSR is able to perform a cleanliness inspection and also clean the food litter on the table by implementing a deep learning technique and planner framework. A lightweight Deep Convolutional Neural Network (DCNN) has been proposed to recognize the food litter on top of the table. In addition, the planner framework was proposed to HSR for accomplishing the table cleaning task which generates the cleaning path according to the detection of food litter and then the cleaning action is carried out. The effectiveness of the food litter detection module is verified with the cleanliness inspection task using Toyota HSR, and its detection results are verified with standard quality metrics. The experimental results show that the food litter detection module achieves an average of 96 % detection accuracy, which is more suitable for deploying the HSR robots for performing the cleanliness inspection and also helps to select the different cleaning modes. Further, the planner part has been tested through the table cleaning tasks. The experimental results show that the planner generated the cleaning path in real time and its generated path is optimal which reduces the cleaning time by grouping based cleaning action for removing the food litters from the table.


Assuntos
Algoritmos , Aprendizado Profundo , Redes Neurais de Computação , Robótica/instrumentação , Saneamento/instrumentação , Alimentos , Humanos , Processamento de Imagem Assistida por Computador , Decoração de Interiores e Mobiliário/instrumentação , Limite de Detecção , Robótica/métodos , Tecnologia Assistiva , Carga de Trabalho
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