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Chem Biodivers ; 14(10)2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28772025

RESUMO

Three new macrocyclic diterpenoids, euphoscopoids A - C (1 - 3), including two new jatrophanes and a new lathyrane, were isolated from the whole plant of Euphorbia helioscopia. Their structures were elucidated by spectroscopic methods. Antifeedant and cytotoxic activities of these isolates were evaluated. All compounds showed significant antifeedant activity against a generalist plant-feeding insect, Helicoverpa armigera, with EC50 values ranging from 2.05 to 4.34 µg/cm2 . In addition, compound 2 showed moderate cytotoxicity against tumor cell lines NCI-H1975, HepG2, and MCF-2, while compounds 1 and 3 were not active at 80 µm. The results suggested not only the defensive function of macrocyclic diterpenoids in E. helioscopia against insect herbivores, but also their potential applications as new natural insect antifeedants.


Assuntos
Diterpenos/farmacologia , Euphorbia/química , Compostos Macrocíclicos/farmacologia , Animais , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Diterpenos/química , Diterpenos/isolamento & purificação , Relação Dose-Resposta a Droga , Comportamento Alimentar/efeitos dos fármacos , Humanos , Compostos Macrocíclicos/química , Compostos Macrocíclicos/isolamento & purificação , Conformação Molecular , Mariposas , Relação Estrutura-Atividade
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