Evaluation of extramedullary plasmacytoma of the larynx with radiologic and histopathological findings.

Extramedullary plasmacytoma (EMP) is a plasma cell neoplasm of soft tissue without bone marrow involvement or other systemic characteristics of multiple myeloma. Approximately 80%-90% of EMPs involve the head and neck region, especially in the nasal cavity, paranasal sinuses, tonsillar fossa, and oral cavity. An EMP of the larynx is extremely rare and is a locally destructive lesion without systemic spread. Clinical features vary depending on the tumor location. A diagnosis is established by histopathology, immunohistochemistry, and a systemic survey to exclude systemic plasma cell proliferative diseases. Extramedullary plasmacytomas are highly radiosensitive and radiotherapy is therefore used as a treatment. In this study, we report on a rare case of EMP of the larynx evaluated with computed tomography and present histopathologic findings for a 74-year-old female patient.

Evaluación del plasmocitoma extramedular de laringe con hallazgos radiológicos e histopatológicos / Evaluation of Extramedullary Plasmacytoma of the Larynx with Radiologic and Histopathological Findings

El plasmocitoma extramedular (PEM) es una neoplasia de células plasmáticas del tejido blando sin afectación de la médula ósea ni otras características sistémicas de mieloma múltiple. Aproximadamente el 80-90% de los PEM afectan a la región de la cabeza y el cuello, especialmente a la cavidad nasal, los senos paranasales, la fosa amigdalina y la cavidad oral. Los casos de PEM de laringe son extremadamente raros y se trata de una lesión destructiva a nivel local sin propagación sistémica. Las características clínicas varían en función de la localización del tumor. El diagnóstico se establece mediante histopatología, inmunohistoquímica y un estudio sistémico para excluir las enfermedades sistémicas de proliferación de células plasmáticas. Los plasmocitomas extramedulares son altamente sensibles a la radiación, por lo que se utiliza la radioterapia como tratamiento. En este estudio, notificamos un caso raro de PEM de laringe evaluado con tomografía computarizada y presentamos los resultados histopatológicos de una paciente de 74 años.(AU)

Extramedullary plasmacytoma (EMP) is a plasma cell neoplasm of soft tissue without bone marrow involvement or other systemic characteristics of multiple myeloma. Approximately 80-90% of EMPs involve the head and neck region, especially in the nasal cavity, paranasal sinuses, tonsillar fossa, and oral cavity. An EMP of the larynx is extremely rare and is a locally destructive lesion without systemic spread. Clinical features vary depending on the tumor location. A diagnosis is established by histopathology, immunohistochemistry, and a systemic survey to exclude systemic plasma cell proliferative diseases. Extramedullary plasmacytomas are highly radiosensitive and radiotherapy is therefore used as a treatment. In this study, we report on a rare case of EMP of the larynx evaluated with computed tomography and present histopathologic findings for a 74-year-old female patient.(AU)

Evaluation of Extramedullary Plasmacytoma of the Larynx with Radiologic and Histopathological Findings. / Evaluación del plasmocitoma extramedular de laringe con hallazgos radiológicos e histopatológicos.

Extramedullary plasmacytoma (EMP) is a plasma cell neoplasm of soft tissue without bone marrow involvement or other systemic characteristics of multiple myeloma. Approximately 80-90% of EMPs involve the head and neck region, especially in the nasal cavity, paranasal sinuses, tonsillar fossa, and oral cavity. An EMP of the larynx is extremely rare and is a locally destructive lesion without systemic spread. Clinical features vary depending on the tumor location. A diagnosis is established by histopathology, immunohistochemistry, and a systemic survey to exclude systemic plasma cell proliferative diseases. Extramedullary plasmacytomas are highly radiosensitive and radiotherapy is therefore used as a treatment. In this study, we report on a rare case of EMP of the larynx evaluated with computed tomography and present histopathologic findings for a 74-year-old female patient.

Ulnar variance according to gender and side during aging: An analysis of 600 wrists.

BACKGROUND: Ulnar variance, or the difference in height between the joint surfaces of the distal radius and ulna, may play a role in several diseases of the wrist. HYPOTHESIS: This study was to conduct a detailed analysis of ulnar variance in a wider case series by dividing the patients' radiographs into groups according to age, gender, and side. MATERIALS AND METHODS: Twenty groups were created in order to investigate the change of ulnar variance according to age, gender, and side. Each group was planned to have 30 wrists. Wrist radiographs were scanned retrospectively, and ulnar variance was measured using the method of perpendiculars. Patients with any arthritic conditions, avascular necrosis, congenital deformities, bone and soft tissue tumors, and previous fractures or surgeries, and those radiographs, which were not at the exact anteroposterior position, and with insufficient technique were not included the study. RESULTS: Six hundrends wrists (300 males [150 right, and 150 left wrists], and 300 females [150 right, and 150 left wrists]) were included in this study. There was a significant difference between the males (median: 0.4, minimum: -3.8, maximum: 5.1) and females (median: 0.85, minimum: -4.8, maximum: 5.7), regardless of the age and side (p=0.043). In the right wrists only (regardless of age), there was also a significant difference between the males (median: 0, minimum: -3.8, maximum: 5.1) and females (median: 0.8, minimum: -3.9, maximum: 5.7) (p=0.025). No statistically significant differences were found within the males and females with regard to aging, or between the sides in the same sex in any decade. In addition, there were no significant differences between the same sides in the males and females in any decade. DISCUSSION: Although this study has one of the larger series in the literature, further studies should be done in different populations and ethnicities to obtain more accurate results, and to understand the relationship between ulnar variance and specific wrist disorders. LEVEL OF EVIDENCE: Level III.