Effect of empowerment theory health education on disease control level and compliance of elderly T2DM.

To study the effect of empowerment theory health education on disease control level and compliance of elderly patients with type 2 diabetes mellitus (T2DM). 200 elderly patients with T2DM admitted to our hospital (January 2017 to December 2019) were included in this study and divided into a control group and an empowerment group by random number method. The control group was given routine health education, while the empowerment group was given empowerment theory health education. The treatment compliance, T2DM-related health literacy, self-management ability, blood glucose level and quality of life of the two groups of patients were evaluated after 3-month follow-up. Before education, the compliance, T2DM-related health literacy, self-management level, blood glucose level and quality of life scores was basically the same in the two groups (P>0.05); after education, the above scores of the two groups were improved (P<0.05) and the improvement in the empowerment group was better than that in the control group (P<0.05). Empowerment theory health education can improve the treatment compliance, disease control level and quality of life of elderly T2DM patients.

Knockdown of GPRC5B alleviates the high glucose-induced inflammation and extracellular matrix deposition of podocyte through inhibiting NF-κB pathway.

BACKGROUND: Diabetes is a serious disease that could greatly increase the risk of cardiovascular complications, whereas the underlying pathology of DN is still unknown. GPRC5B is a member of the RAIG subfamily of type 3 (family C) GPCR, and its role in DN is still unclear. OBJECTIVE: To unveil the role of GPRC5B in diabetic nephropathy (DN) progression and investigate the potential signaling pathway. MATERIALS AND METHODS: Podocytes were stimulated with high glucose and expression of GPRC5B was analyzed by qPCR and western blot. Then the level of GPRC5B was depleted by siRNA transfection and inflammatory cytokine level was monitored by ELISA assay. The ECM depostion and the activation of NF-κB pathway were detected by Immunoblot. RESULTS: We investigated the possible role of GPRC5B in the pathology of diabetic nephropathy. We found GPRC5B was highly expressed in high glocuse (HG) induced podocytes. The depletion of GPRC5B inhibited HG induced cell inflammation. In addition, the ablation of GPRC5B suppressed the HG induced ECM deposition. We further found GPRC5B could alleviate the inflammation and extracellular matrix deposition of HG-induced podocytes through NF-κB pathway. CONCLUSION: We therefore thought GPRC5B could serve as a promising target for the treatment of diabetic nephropathy. G-protein-coupled receptors.