Real-World Evidence of Tofacinitib in Ulcerative Colitis: Short-Term and Long-Term Effectiveness and Safety.

INTRODUCTION: The objective of this study was to assess the durability, short-term and long-term effectiveness, and safety of tofacitinib in ulcerative colitis (UC) in clinical practice. METHODS: This is a retrospective multicenter study including patients with UC who had received the first tofacitinib dose at least 8 weeks before the inclusion. Clinical effectiveness was based on partial Mayo score. RESULTS: A total of 408 patients were included. Of them, 184 (45%) withdrew tofacitinib during follow-up (mean = 18 months). The probability of maintaining tofacitinib was 67% at 6 m, 58% at 12 m, and 49% at 24 m. The main reason for tofacitinib withdrawal was primary nonresponse (44%). Older age at the start of tofacitinib and a higher severity of clinical activity were associated with tofacitinib withdrawal. The proportion of patients in remission was 38% at week 4, 45% at week 8, and 47% at week 16. Having moderate-to-severe vs mild disease activity at baseline and older age at tofacitinib start were associated with a lower and higher likelihood of remission at week 8, respectively. Of 171 patients in remission at week 8, 83 (49%) relapsed. The probability of maintaining response was 66% at 6 m and 54% at 12 m. There were 93 adverse events related to tofacitinib treatment (including 2 pulmonary thromboembolisms [in patients with risk factors] and 2 peripheral vascular thrombosis), and 29 led to tofacitinib discontinuation. DISCUSSION: Tofacitinib is effective in both short-term and long-term in patients with UC. The safety profile is similar to that previously reported.

Mo-Catalyzed One-Pot Synthesis of N-Polyheterocycles from Nitroarenes and Glycols with Recycling of the Waste Reduction Byproduct. Substituent-Tuned Photophysical Properties.

A catalytic domino reduction-imine formation-intramolecular cyclization-oxidation for the general synthesis of a wide variety of biologically relevant N-polyheterocycles, such as quinoxaline- and quinoline-fused derivatives, and phenanthridines, is reported. A simple, easily available, and environmentally friendly dioxomolybdenum(VI) complex has proven to be a highly efficient and versatile catalyst for transforming a broad range of starting nitroarenes involving several redox processes. Not only is this a sustainable, step-economical as well as air- and moisture-tolerant method, but also it is worth highlighting that the waste byproduct generated in the first step of the sequence is recycled and incorporated in the final target molecule, improving the overall synthetic efficiency. Moreover, selected indoloquinoxalines have been photophysically characterized in cyclohexane and toluene with exceptional fluorescence quantum yields above 0.7 for the alkyl derivatives.

[New epidemiologic patterns and risk factors in renal cancer]. / Nuevos patrones epidemiológicos y factores de riesgo en cáncer renal.

Incidence of renal carcinoma, one of the most fatal solid neoplasms, has steadily increased in Western society. Moreover, these tumors are being increasingly detected in their early stages. As with most cancers, the underlying causes of the disease remain unknown. However, understanding of pathogenesis of this tumor is rapidly advancing, and will allow for new treatments for advanced disease. Understanding of the influence of easily avoidable risk factors may allow for prevention of thousands of deaths caused by renal cancer.

Nuevos patrones epidemiológicos y factores de riesgo en cáncer renal / New epidemiologic patterns and risk factors in renal cancer

El carcinoma renal constituye una de las neoplasias sólidas más letales. En la sociedad occidental se ha producido un constante aumento de la incidencia de este tumor, además de un incremento en la detección de tumores en estadíos precoces. Como ocurre en la mayoría de los cánceres, las causas de la enfermedad permanecen en gran medida desconocidas. Sin embargo, el conocimiento sobre la patogenia última de este tumor avanza rápidamente, permitiendo nuevos tratamientos para la enfermedad avanzada. El conocimiento de la influencia de factores de riesgo fácilmente evitables puede permitir evitar miles de muertes causadas por el cáncer renal (AU)

Incidence of renal carcinoma, one of the most fatal solid neoplasms, has steadily increased in Western society. Moreover, these tumors are being increasingly detected in their early stages. As with most cancers, the underlying causes of the disease remain unknown. However, understanding of pathogenesis of this tumor is rapidly advancing, and will allow for new treatments for advanced disease. Understanding of the influence of easily avoidable risk factors may allow for prevention of thousands of deaths caused by renal cancer (AU)

Riñones parejos en trasplante / Paired kidneys in transplant

Objetivos: Muchos factores afectan la supervivencia del injerto y paciente en el resultado de un trasplante renal. Estos factores dependen tanto del receptor como del donante. Realizamos un estudio intentando obviar factores que dependen del donante. Revisamos los riñones parejas provenientes de un mismo donante cadáver. Pacientes y métodos: Analizamos los factores de riesgo en la evolución y seguimiento de 556 trasplantes renales que corresponden a 278 parejas de riñones. Describimos sus diferencias, su significación, la supervivencia de injerto y paciente, su funcionalidad a 3 y 5 años y los factores de riesgo implicados en su función. Se estudian variables inmunológicas y no inmunológicas intentando explicar los resultados inferiores en los injertos que se implantan en segundo lugar. Se reagrupan los riñones parejos en aquellos que no mostraron función pareja inicial dentro de la misma pareja. Resultados: Los resultados arrojan un discreto empeoramiento en la supervivencia de injerto y paciente para el grupo de segundo implante, cifras superiores de creatinina, sin obtener significación estadística. El estudio por regresión de Cox solo establece como factores de riesgo el rechazo precoz (inferior a tres meses) y la tasa de incompatibilidad DR. Conclusiones: Este modelo de riñones parejos podría acercarnos de forma más adecuada al análisis de los factores de riesgo en trasplante de donante cadáver, si más pacientes se analizan de la misma forma. Los riñones parejas provenientes del mismo donante no muestran igual función a pesar de compartir las mismas condiciones del donante y del manejo peroperatorio (AU)

Objectives: Many factors affect the graft and patient survival on the renal transplant outcome. These factors depend so much of the recipient and donor. We accomplished a study trying to circumvent factors that depend on the donor. We checked the paired kidneys originating of a same donor cadaver. Patients and method: We examined the risk factors in the evolution and follow-up in 278 couples of kidney transplant. We describe their differences, significance, the graft and patient survival, their functionality in 3 and 5 years and the risk factors implicated in their function. We study immunogenic and no immunogenic variables, trying to explain the inferior results in the grafts that are established secondly. We regroup the paired kidneys in those that they did not show paired initial function within the same couple. Results: The results yield a discreet deterioration in the graft and patient survival for second group establish, superior creatinina concentration, without obtaining statistical significance. The Cox regression study establishes the early rejection (inferior to three months) and DR incompatibility values like risk factors. Conclusions: This model of paired kidneys would be able to get close to best-suited form for risk factors analysis in kidney transplant from cadaver donors, if more patients examine themselves in the same way. The paired kidneys originating from the same donor do not show the same function in spite of sharing the same conditions of the donor and perioperative management (AU)