Captivity reduces hippocampal volume but not survival of new cells in a food-storing bird.

In many naturalistic studies of the hippocampus wild animals are held in captivity. To test if captivity itself affects hippocampal integrity, adult black-capped chickadees (Poecile atricapilla) were caught in the fall, injected with bromodeoxyuridine to mark neurogenesis, and alternately released to the wild or held in captivity. The wild birds were recaptured after 4-6 weeks and perfused simultaneously with their captive counterparts. The hippocampus of captive birds was 23% smaller than wild birds, with no hemispheric differences in volume within groups. Between groups there was no statistically significant difference in the size of the telencephalon, or in the number and density of surviving new cells. Proximate causes of the reduced hippocampal volume could include stress, lack of exercise, diminished social interaction, or limited caching opportunity-a hippocampal-dependent activity. The results suggest the avian hippocampus-a structure essential for rapid, complex relational and spatial learning-is both plastic and sensitive, much as in mammals, including humans.

Voluntary running distance is negatively correlated with striatal dopamine release in untrained rats.

This study examined the relationship between voluntary running distance and glutamate- and K+-stimulated dopamine release in the striatum (nucleus accumbens and caudate-putamen) of male Long-Evans rats. Twenty-one rats were housed individually in cages with attached running-wheels for 1 week. There was a 19-fold variability between rats in voluntary running distances over this period (range = 2.3-44.6 km). The average distance completed during the week was 16 +/- 2.8 km. There was a strong positive correlation between the running distances completed during the first 24 h (day 1) and the last 24 h. Certain rats were therefore inclined to run from the start. The average daily running distance (2.4 +/- 0.4 km per day) was negatively correlated with the weight of the rat (r = -0.82). Glutamate-stimulated release of dopamine was not a significant predictor of voluntary running distance. However, the average daily running distance was negatively correlated with K+-stimulated dopamine release in the nucleus accumbens core and caudate-putamen but not the nucleus accumbens shell. The present findings suggest that decreased depolarization-induced release of striatal dopamine may be a predictor of hyperactivity. The results show, in a normal population of Long-Evans rats, that there are, at the end of the continuum, rats that display some of the neurochemical and behavioral characteristics of a rat model for attention-deficit hyperactivity disorder.