Chemical shift imaging: preliminary experience as an alternative sequence for defining the extent of a bone tumor.

OBJECTIVE: To investigate chemical shift imaging (CSI) with in-phase and opposed-phase (OP) gradient-echo sequences as an alternative sequence to spin-echo T1 imaging for defining intra-medullary skeletal tumor extent. METHODS AND MATERIALS: This retrospective HIPAA-compliant study was approved by our institutional institutional review board (IRB). Twenty-three subjects with histologically-proven tumors (17 appendicular, 6 axial) underwent magnetic resonance imaging (MRI) with T1-weighted spin echo (T1SE), fluid-sensitive, CSI, and contrast-enhanced T1 sequences. One observer recorded intra-medullary tumor extent (millimeters), with 153 total measurements on each sequence. Red marrow grade [0 (none), 1 (<50%), 2 (50-75%) and 3 (>75%)] in each bone was recorded. Tumor extent on different sequences was compared (Student's t-test); the impact of red marrow grade on measurements was assessed (Spearman's correlation coefficient). RESULTS: There was good agreement between measurements of tumor extent on T1SE and CSI sequences in all cases (T1SE-CSI measurement difference range 0-13.2 mm, P>0.05). Measurements from other sequences were significantly different from those of T1SE (P<0.05). As red marrow grade in the bone increased, a significant increase in measurement difference obtained on T1SE and CSI sequences was observed (P<0.001). CONCLUSIONS: CSI is a potential alternative technique to T1SE imaging for defining the intra-medullary extent of a bone tumor, possibly especially useful in regions with abundant red marrow. ADVANCE IN KNOWLEDGE: CSI could be an alternative technique to T1SE imaging for defining the intra-medullary extent of bone tumor by abundant red marrow in the surrounding bone.

"Cystic"-appearing soft tissue masses: what is the role of anatomic, functional, and metabolic MR imaging techniques in their characterization?

Although conventional MR imaging with contrast-enhanced T1-weighted sequences is of paramount importance for evaluating soft tissue masses, noncontrast MR sequences have emerged that facilitate their characterization. In this article, the utility and pitfalls of conventional MR imaging with T1-weighted, fluid-sensitive, and contrast-enhanced sequences will be discussed, along with that of functional (diffusion weighted imaging) and metabolic (proton MR spectroscopy) non-contrast-enhanced techniques for the purpose of soft tissue mass characterization. In particular, we discuss the application of these techniques to differentiating neoplastic or inflammatory masses that have high fluid content from benign cysts, as this distinction is a common pitfall of conventional sequences.