The significance of angiogenesis and tumoral proliferation in renal cell carcinoma.

Angiogenesis represents one of the most important factors of the tumor proliferation. Renal carcinoma with clear cells is highly vascularized. Knowing numerous quantification systems of tumor angiogenesis, we used a simple one, the evaluation of the relative vascular density. We studied 61 cases with partial or total nephrectomy performed in the Urology Department of Timisoara County Hospital. We correlated the intensity of angiogenesis with a tumor proliferation factor PCNA (proliferating cell nuclear antigen) and with the monoclonal antibody PC10. Correlation of the two immunohistochemical methods with the degree of the tumor differentiation suggested an inverse ratio between vascular density and tumor proliferation degree.

[Infected wound treatment using negative pressure atmosphere]. / Tratamentul plagilor supurate în atmosfera cu presiune negativa.

The aim of this clinical study is the presentation of a adjuvant therapy for chronic or infected wounds. Unwanted complication in any surgical branch the infected wound benefits primarily of surgical debridement. The treatment in negative pressure atmosphere of the complicated wound is a valuable adjuvant treatment due to volume reduction of the soft tissue defect, stimulation of the granulation tissue formation, decreasing of the bacterial contamination, permanent secretion drainage in a closed system with local continuous or intermittent lavage possibility. The patented V.A.C. system is the ideal but expensive option for this therapy. However good results were obtained in the treatment of difficult infected wounds by building a system using a auto adhesive incision drape and Redon drainage.

[Minimally invasive surgical treatment of recent achilles tendon rupture]. / Tratament chirurgical minim invaziv al rupturii recente de tendon ahilian.

The Achilles tendon rupture represents a acute, invalidating pathology with a increasing trend. It affects the young active adult and the treatment indications have not developed a standard yet. The treatment can be conservative (cast immobilization) or operative. The aim of the study is the widespread of the authors experience with the percutaneous suture of the fresh Achilles tendon rupture, a accessible and effective treatment method of a lesion which is of a larger interest then just of the orthopedic surgeon. This minimal invasive technique combines the benefits of the conservative treatment--low complication incidence--with those of the surgical treatment were the union rate is higher. The suture material makes no difference. The use of 1,5 mm PDS cord or normal, braided 0 nylon has offered the same good end result. The costs are lowered by the short operative time and hospitalization period and the patients returned to the anterior activity at 6-8 weeks after injury. At the same time the cosmetic result is very good. This technique could be set as a standard for the treatment of the fresh Achilles tendon rupture.