RESUMO
OBJECTIVE: To investigate effects of ethanol extract of Abrus precatorius leaves (EAPL) on egg albumin induced mast cell degranulation in mice and passive cutaneous anaphylaxis in rats. METHODS: In present study ethanol extract of Abrus precatorius leaves (EAPL) at doses of 100, 125, 150 mg/kg i.p were evaluated for preliminary phytochemical screening, acute toxicity studies and egg albumin induced mast cell degranulation in mice and passive cutaneous anaphylaxis in rats. RESULTS: The results of present investigation showed that the LD(50) of EAPL is more than 1 300 mg/kg. EAPL (100-150 mg/kg, i.p.) significantly protect egg albumin induced degranulation of mast cell and inhibit area of leakage of dye in passive cutaneous anaphylaxis. Phytochemical studies observed presence of saponin, alkaloids, flavonoids, and glycosides. CONCLUSIONS: In conclusion EAPL possesses anti asthmatic potential.
Assuntos
Abrus/química , Antialérgicos/farmacologia , Fatores Imunológicos/farmacologia , Mastócitos/efeitos dos fármacos , Extratos Vegetais/farmacologia , Albuminas/imunologia , Anafilaxia/tratamento farmacológico , Animais , Antialérgicos/efeitos adversos , Antialérgicos/isolamento & purificação , Degranulação Celular/efeitos dos fármacos , Fatores Imunológicos/efeitos adversos , Fatores Imunológicos/isolamento & purificação , Dose Letal Mediana , Camundongos , Extratos Vegetais/efeitos adversos , Extratos Vegetais/isolamento & purificação , RatosRESUMO
In world Helminthes infections are the most widespread of all the infections in humans. The morbidity due to parasitic diseases has been increasing in our population. The gastrointestinal helminthes become resistant to the currently available anthelmintic drugs. Anthelmintic substances having considerable toxicity to human beings are present in foods derived from livestock, posing a serious threat to human health. Due to this, there is a need to derive new chemical substances from natural sources, for helminthes control. In this study, volatile oil isolated from Eucalyptus globulus Labill was evaluated for its anthelmintic activity on adult Indian earthworms, Pheretima posthuma, which have anatomical and physiological resemblance with the intestinal roundworm parasites of human beings. In concentrations of 0.05, 0.01 and 0.15 ml/ml, respectively, all the oil samples showed potent anthelmintic activity as compared to that of the standard drug albendazole at a concentration of 10 mg/ml.
RESUMO
Various extracts of Ficus bengalensis bark was screened for it's antiallergic and antistress potential in asthma by milk-induced leucocytosis and milk-induced eosinophilia. Aqueous, ethanol, and ethyl acetate extracts showed significant decrease in leucocytes and eosinophils in the order given while petroleum ether and chloroform extracts were inactive. This shows the application of polar constituents of F. bengalensis bark as antistress and antiallergic agents in asthma.
