RESUMO
The collapse of mining tailing dams in Brumadinho, Minas Gerais, Brazil, that occurred in 2019 was one of the worst environmental and social disasters witnessed in the country. In this sense, monitoring any impacted areas both before and after the disaster is crucial to understand the actual scenario and problems of disaster management and environmental impact assessment. In order to find answers to that problem, the aim of this study was to identify and analyze the spatiality of the impacted area by rupture of the tailing dam of the Córrego do Feijão mine in Brumadinho, Minas Gerais, by using orbital remote sensing. Land use and land occupation, phytoplankton chlorophyll-a, water turbidity, total suspended solids on water, and carbon sequestration efficiency by vegetation (CO2Flux) were estimated by orbital imagery from the Landsat-8/OLI and MSI/Sentinel-2 sensors in order to assess the environmental impacts generated by the disaster. Data were extracted from spectral models in which the variables that best demonstrated the land use variation over the years were sought. Mean comparison by t-test was performed to compare the time series analyzed, that is, before and after the disaster. Through the analysis of water quality, it was observed that the environmental impact was calamitous to natural resources, especially water from Córrego do Feijão.
Assuntos
Monitoramento Ambiental , Tecnologia de Sensoriamento Remoto , Brasil , Meio Ambiente , MineraçãoRESUMO
In this work, a number of lipidic amino alcohols wereas synthesized and evaluated in vitro on cultures of Leishmania amazonensis and Leishmania chagasi. Nine amino alcohols showed inhibition of L. chagasi growth, and seven of them showed inhibition of L. amazonensis with IC(50) below 10 microm. Compound 11f was more active than the reference drug amphotericin B against L. chagasi promastigote forms.
Assuntos
Amino Álcoois/síntese química , Leishmania/efeitos dos fármacos , Tripanossomicidas/síntese química , Amino Álcoois/química , Amino Álcoois/farmacologia , Anfotericina B/farmacologia , Humanos , Leishmania/crescimento & desenvolvimento , Tripanossomicidas/química , Tripanossomicidas/farmacologiaRESUMO
A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 microg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 microg/mL.
Assuntos
Amino Álcoois/farmacologia , Antituberculosos/farmacologia , Diaminas/farmacologia , Mycobacterium tuberculosis/efeitos dos fármacos , Amino Álcoois/síntese química , Antituberculosos/química , Diaminas/síntese química , Testes de Sensibilidade MicrobianaRESUMO
A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 µg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 µg/mL.
Assuntos
Amino Álcoois/farmacologia , Antituberculosos/farmacologia , Diaminas/farmacologia , Mycobacterium tuberculosis/efeitos dos fármacos , Amino Álcoois/síntese química , Antituberculosos/química , Diaminas/síntese química , Testes de Sensibilidade MicrobianaRESUMO
A series of N- and C-alkylated amino alcohols and of their protected galactopyranosyl derivatives was synthesized and evaluated for antitubercular activity. Five of these compounds displayed good activity, with a MIC below 12.5mug/mL. The presence of the carbohydrate slightly affected the antibacterial activity.