1.
Chem Pharm Bull (Tokyo)
; 58(8): 1107-10, 2010 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20686270
RESUMO
A variety of 5,4'-disubstituted flavones, which are anticipated to be androgen receptor antagonists to treat diseases mediated by the androgen receptor, were synthesized. It was found that an intramolecular ipso-substitution reaction via cesium enolate using 2-fluoro-6-hydroxyacetophenone and various benzoyl chlorides was effective in the preparation of 5-hydroxy-4'-alkylflavones.