1.
Org Lett
; 20(19): 6178-6182, 2018 10 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30230338
RESUMO
The biosynthetic pathway of brassicicenes, derived from the phytopathogen Pseudocercospora fijiensis, was fully reconstituted. Heterologous expression of the eight genes highly expressed in infected leaf tissues generated a new brassicicene derivative as a final product. Together with the characterization of P450 from Alternaria brassicicola, a late stage of the biosynthetic pathway, which generates remarkable structural diversity, has been proposed. Notably, a unique P450 that converts 3 to the structurally distinct 4 and 6 was identified.
Assuntos
Ascomicetos/metabolismo , Diterpenos/metabolismo , Alternaria/genética , Ascomicetos/genética , Aspergillus oryzae/metabolismo , Biocatálise , Vias Biossintéticas , Genes Fúngicos , Estrutura Molecular , Família Multigênica , Oxirredução , Folhas de Planta/microbiologia
2.
Gastrointest Endosc
; 68(5): 1008; discussion 1009, 2008 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18657805