[Combined action of nucleosides and alpha-interferon in inhibiting the reproduction of the herpes simplex type-II virus]. / Sochetannoe deistvie nekotorykh nukleozidov i al'fa-interferona pri ingibirovanii reproduktsii virusa prostogo gerpesa II tipa.

Therapeutic effect of four combinations of antiherpetic chemical preparations--acyclovir (ACV), 9-beta-D-arabinofuranosyladenine (ARA-A) and E-5-(2-bromovinyl)-2'-desoxyuridine (BVDU)--has been studied. Mutual enhancement was observed in all the combinations studied, except for ACV and ARA-A combination, where partial antagonism was observed. ACV + BVDU was shown to be the most optimal combination, with the minimum inhibitory concentration (MIC) of BVDU decreasing 400-fold. A significant enhancement of nucleosides antiviral effect was noted when the human leucocyte interferon was used with the combinations. Along with synergistic effect during the interaction of alpha-interferon with ACV the antagonism in the combination of alpha-interferon with ARA-A was observed.

[Action of interferons on the reproduction of herpes simplex viruses in in vitro experiments]. / Deistvie interferonov na reproduktsiiu virusov prostogo gerpesa v opytakh in vitro.

Tests of various interferon preparations (alpha, alpha2, alpha-beta, beta, and swine leukocyte) in human diploid fibroblast culture for the presence or absence of cytopathic effect of herpes simplex viruses type 1 and 2 (HSV-1 and HSV-2) demonstrated antiviral effect of all interferons with the exception of lymphoblastoid one. Preparations of alpha and swine leukocyte interferons were the most effective for inhibition of HSV-1 reproduction. Recombinant interferon was 10-fold and fibroblast interferon 100-fold less active for HSV-1 than alpha- and swine leukocyte interferons. All the interferons under study (alpha-beta) were similarly active in their antiviral effect on HSV-2 reproduction.