Long-term results after treatment of pertrochanteric femoral fractures with percutaneous compression plate (PCCP).

OBJECTIVE: This study sought to evaluate the long-term osteosynthesis results for AO/OTA 31.A1-A2 pertrochanteric fractures treated with the percutaneous compression plate (PCCP). MATERIALS AND METHODS: This investigation was a retrospective observational descriptive study of 335 patients, with a minimum follow-up of 2 years and a maximum follow-up of 8 years (2004-2011). RESULTS: The average post-operative hospital stay was 6.2 days, and the average decrease in haemoglobin levels after the intervention was 2.7 mg/dL, with transfusion required for one-third of the patients. Complications related to the implant were observed in 4.2 % of patients; the most notable complication was cut-out (2.4 % of patients), and 3 cases involved pseudarthrosis with breakage of the implant (0.9 % of patients). CONCLUSIONS: From the results obtained in this study and an analysis of previously published work, we believe that the PCCP may be the implant of choice for AO/OTA 31.A1-A2 fractures.

Systematic review with meta-analysis: the incidence and prevalence of eosinophilic oesophagitis in children and adults in population-based studies.

BACKGROUND: The recognition of eosinophilic oesophagitis (EoE) has risen sharply, but its current epidemiology is still under debate. AIM: To estimate accurately the prevalence and incidence rates of EoE, by a systematic review and meta-analysis. METHODS: MEDLINE, EMBASE and SCOPUS databases were searched for population-based studies on the epidemiology of EoE. Pooled incidence and prevalence rates, male:female and children:adult ratios, and geographical and temporal variations were calculated with random-effects models. RESULTS: The search yielded 1334 references; the final quantitative summary included 13 population-based studies from North America, Europe and Australia, with the results showing high heterogeneity. The pooled EoE incidence rate was 3.7/100 000 persons/year [95% confidence interval (CI): 1.7-6.5] and was higher for adults (7; 95% CI: 1-18.3) than for children (5.1; 95% CI: 1.5-10.9). The pooled prevalence of EoE was 22.7 cases/100 000 inhabitants (95% CI: 12.4-36), rising to 28.1 (95% CI: 13-49) when studies with a lower risk of bias were considered; prevalence was higher in adults than in children (43.4; 95% CI: 22.5-71.2 vs. 29.5; 95% CI: 17.5-44.7, respectively), and in American compared to European studies. A steady rise in EoE incidence and prevalence rates was observed upon comparison of studies conducted before and after 2008. No significant publication bias was found. CONCLUSIONS: Eosinophilic oesophagitis is an increasingly common diagnosis in North America and Europe. The population-based incidence and prevalence of eosinophilic oesophagitis vary widely across individual studies, probably due to variations in diagnosis and risk of bias of research. More prospective, large-scale, multicenter studies are needed to evaluate reported data.

A case-control study of post-operative endophthalmitis diagnosed at a Spanish hospital over a 13-year-period.

A retrospective case-control study of patients who had undergone cataract extraction at a Spanish hospital over a 13-year period was conducted to identify the risk factors for developing post-operative endophthalmitis (POE). During the study period, the type of antibiotic prophylaxis was changed from subconjunctival gentamicin to the addition of both vancomycin and gentamicin to the irrigating solution. The overall incidence of POE was 0·19% (35 cases/18 287 operations). For the period prior to the change in antibiotic prophylaxis, the incidence rate of POE was 3·4 cases/1000 operations while in the latter period the incidence rate decreased to 0·34 cases/1000 operations. All patients who presented a virulent microorganism had a final visual acuity worse than 20/200. The only significant risk factor identified was the type of prophylaxis used (odds ratio 1·97, 95% confidence interval 0·94-4·14, P = 0·07). There were no significant differences between cases and controls although choice of surgeon approached significance.

A checklist for critical appraisal of indirect comparisons.

The aim of this study was to develop a user-friendly checklist for critical appraisal of indirect comparisons of drugs, considering clinical, methodological/statistical and quality aspects, mainly to be applied in drug evaluation in the decision-making context. After conducting a review of the literature, we used group consensus to establish the key points of the checklist, focusing mainly on indirect comparisons, but including topics related to network meta-analysis or multiple treatment comparisons. The coordinating group elaborated the first draft, which was reviewed by external experts, re-evaluated by the coordinating group and finally assessed by 23 drug evaluation experts trained in indirect comparisons, who applied the checklist to one study. The Kappa index of agreement was calculated and the final checklist was developed by group consensus including the external experts. The checklist has two parts. The first consists of three eliminatory key questions while the second includes 17 items: 5 regarding quality, 5 regarding clinical issues and 7 dealing with methodology/statistics. The median kappa values of the 23 evaluations were 0.83 (range 0.67-0.93), 0.61 (0.54-0.91) and 0.36 (0.22-1) with regard to quality, clinical aspects and methodology/statistics, respectively. A structured checklist was developed to facilitate critical appraisal of key issues in indirect comparisons, including comments for assessing the consequences of its application to drug evaluation in the decision-making context. Agreement between reviewers in clinical and quality items was good, but weaker in methodology/statistics ones.

A Spanish multicenter study to estimate the prevalence and incidence of chronic pancreatitis and its complications.

BACKGROUND AND OBJECTIVE: No nation-wide epidemiological study on the incidence and prevalence of chronic pancreatitis (CP) had been thus far carried out in Spain. Our goal is to estimate the prevalence and incidence of CP, as well as to determine the diagnostic and therapeutic criteria used in Spanish pancreas units. METHODS: An observational, descriptive study of hospital pancreas units in Spain. CP-related epidemiology, etiology, manifestations, diagnostic tests, functional complications, and treatments were all assessed using a structured questionnaire. Overall results were estimated by weighting cases in each site. RESULTS: Information was collected from six pancreas units with a sample frame of 1,900,751 inhabitants. Overall prevalence was 49.3 cases per 105 population (95 % CI, 46 to 52) and incidence was 5.5 cases per 105 inhabitant-years (95 % CI, 5.4 to 5.6). Most common etiologies included tobacco and alcoholism, which were associated with three in every four cases. The most prevalent symptoms were recurring pain (48.8 %) and chronic abdominal pain (30.6 %). The most widely used diagnostic method was echoendoscopy (79.8 %), CT (computerized tomography) (58.7 %), and MRI (magnetic resonance imaging)/MRCP (magnetic resonance cholangiopancreatography) (55.9 %). Most prevalent morphologic findings included calcifications (35 %) and pseudocysts (27 %). Exocrine (38.8 %) and endocrine (35.2 %) pancreatic insufficiency had both a similar frequency. Treatments used were rather heterogeneous among sites, with enzyme replacement therapy (40.7 %) and insulin (30.9 %) being most commonly used. CONCLUSIONS: Pancreas units amass a significant number of both prevalent and incident CP cases. Patients seen in these units share a similar typology, and differences between units are greater regarding diagnostic and therapeutic strategies.

Systematic review: the association between eosinophilic oesophagitis and coeliac disease.

BACKGROUND: The relationship between eosinophilic oesophagitis (EoE) and coeliac disease (CD) remains controversial, with studies yielding varied results. AIM: To systematically review the evidence of a possible association between both diseases. METHODS: Electronic searches were performed with keywords relating to EoE and CD in the MEDLINE, EMBASE and SCOPUS databases. Summary estimates were calculated. A random-effects model was used depending on heterogeneity (I(2) ). Publication bias was assessed with the aid of funnel plot analysis, along with the Begg-Mazumdar, Harbord and Egger tests. RESULTS: The search yielded 197 references; 30 were included in the quantitative summary, with most of these presenting methodological inconsistencies. Significant publication bias in favour of short studies reporting positive associations between both diseases was documented. The prevalence of EoE in CD ranged from 0% to 10.7% (I(2)  = 78.9%). Prevalence of CD in EoE varied between 0.16% and 57.1% (I(2)  = 89%). One high-quality, prospective, randomly selected, population-based study documented a 1.1% prevalence of CD, with no patients presenting EoE. Clinical and methodological heterogeneity hindered the performance of quantitative summaries for prevalence data. A gluten-free diet was effective in achieving histological remission of EoE in 32.1% of coeliac patients (95% confidence interval, 14.9-52.2%; I(2)  = 52.2%), which was similar to that expected for wheat elimination in EoE patients. CONCLUSIONS: While a lack of valid studies prevents us from completely ruling out a true association between EoE and CD, currently available evidence does not support this hypothesis. Indeed, the only epidemiological study with sufficient validity points to the independence of both diseases.

Anestesia subaracnoidea y anestesia general en el tratamiento quirúrgico de la hernia inguinal en pacientes ambulatorios. Análisis comparativo de coste-efectividad / Spinal anesthesia versus general anesthesia in the surgical treatment of inguinal hernia. Cost-effectiveness analysis

Objetivo. Comparar los costes variables en relación con la efectividad clínica de la utilización de anestesia general frente a anestesia subaracnoidea en la cirugía ambulatoria de la hernia inguinal. Material y métodos. Estudio observacional, de cohortes, retrospectivo, con medición y análisis del coste-efectividad, realizado en una unidad de cirugía ambulatoria de un hospital general entre enero de 2010 y diciembre de 2011. Se incluyeron pacientes mayores de 18 años con tratamiento quirúrgico de la hernia inguinal primaria unilateral. Los tiempos de inducción anestésica y permanencia en quirófano y en unidad de recuperación postanestésica, la efectividad anestésica (incidencia de efectos adversos y el grado de bienestar del paciente) y los costes variables asociados al consumo de fármacos y utilización de recursos humanos fueron comparados. Resultados. Se incluyeron 218 pacientes, el 87,2% hombres, con una edad media de 53 años (rango 18 a 85 años). Ciento treinta y nueve (63,76%) pacientes recibieron anestesia subaracnoidea, y 79 (36,2%), anestesia general. La permanencia en recuperación postanestésica fue de 337,6 ± 160,2 min en el grupo de anestesia subaracnoidea y de 210,0 ± 97,5 min para el grupo de anestesia general (p < 0,001). Los costes de los fármacos para anestesia general fueron mayores que para subaracnoidea (86,2 ± 8,3 frente a 18,7 ± 7,2). La diferencia del coste total entre ambas técnicas fue de 115,8 Euros, mayor para el grupo de anestesia subaracnoidea (p < 0,001). Conclusiones. La anestesia subaracnoidea y la general muestran una efectividad similar, pero los costes globales para la primera son mayores que para la segunda. La relación coste-efectividad es más favorable para la anestesia general que para la subaracnoidea en hernioplastia ambulatoria (AU)

Objective. To compare the costs related to the clinical effectiveness of general anesthesia versus spinal anesthesia in inguinal hernioplasty ambulatory surgery. Material and methods. An observational, retrospective cohort study measurement and analysis of cost-effectiveness, in the ambulatory surgery unit of a general hospital. All patients over 18 years of age diagnosed with primary inguinal hernia and scheduled for unilateral hernioplasty between January 2010 and December 2011 were included. Duration of anesthetic induction, length of stay in both the operating room, and in the post-anesthesia care unit, the anesthetic effectiveness (the incidence of adverse effects and the patient's comfort level), and variable economic costs associated with the use of drugs, as well as the use of human resources, were compared. Results. The final analysis included 218 patients, 87.2% male, with a mean age of 53 years (range: 18-85 years). Of these, 139 (63.76%) received subarachnoid anesthesia and 79,(36.2%) general anesthesia. The length of time a patient remained in the post-anesthesia care unit was 337.6 ± 160.2 min in the subarachnoid anesthesia group, and 210.0 ± 97.5 min for the general anesthesia group (P < .001). Costs of drugs for general anesthesia were higher than that for subarachnoid anesthesia (86.2 ± 8.3 vs. 18.7 ± 7.2). The total cost difference between the 2 techniques was Euros 115.8 more for subarachnoid anesthesia (P < .001). Conclusions. Both techniques showed similar effectiveness. The overall costs for subarachnoid anesthesia were greater than for the general. The cost-effectiveness of general anesthesia is better for outpatient inguinal hernia repair surgery (AU)

Second-trimester fetal aberrant right subclavian artery: original study, systematic review and meta-analysis of performance in detection of Down syndrome.

OBJECTIVES: First, to estimate the prevalence of fetal aberrant right subclavian artery (ARSA) in our population and its association with Down syndrome. Second, to determine the feasibility of ultrasound to visualize ARSA in the three planes. Finally, to carry out a systematic review of the literature on the performance of second-trimester ARSA to identify fetuses with Down syndrome. METHODS: ARSA was assessed by ultrasound in the axial plane and confirmed in the longitudinal and coronal planes during the second half of pregnancy in women attending our unit (from February 2011 to December 2012). A search of diagnostic tests for the assessment of ARSA was carried out in international databases. Relevant studies were subjected to a critical reading, and meta-analysis was performed with Meta-DiSc. RESULTS: Of the 8781 fetuses in our population (mean gestational age: 24 ± 5.4 weeks), 22 had Down syndrome. ARSA was detected in the axial view in 60 cases (0.7%) and confirmed in the coronal view in 96.7% and in the longitudinal view in 6.7% (P < 0.001). Seven cases with ARSA had Down syndrome and all were in the non-isolated-ARSA group. The estimates of positive likelihood ratio (LR) were 0 for isolated ARSA and 199 (95% CI, 88.9-445.2) for non-isolated ARSA. In the systematic review, six studies were selected for quantitative synthesis. The pooled estimates of positive and negative LRs for global ARSA were, respectively, 35.3 (95% CI, 24.4-51.1) and 0.75 (95% CI, 0.64-0.87). For isolated ARSA, the positive and negative LRs were 0 (95% CI, 0.0-14.7) and 0.98 (95% CI, 0.94-1.02), respectively. CONCLUSIONS: The prevalence of ARSA seems close to 1%. The coronal plane is the most suitable for its confirmation after detection in the axial plane. Detection of isolated or non-isolated ARSA should guide decisions about karyotyping given that isolated ARSA shows a weak association with Down syndrome.

[Microbiological study of infectious endophthalmitis with positive culture within a 13 year-period]. / Estudio microbiológico de los casos de endoftalmitis infecciosa con cultivo positivo en un periodo de 13 años.

INTRODUCTION: Our objectives are to describe the microbial spectrum and antimicrobial susceptibility of isolates from patients with culture-proven endophthalmitis. MATERIAL AND METHODS: Retrospective study of patients with microbiological diagnosis of endophthalmitis treated at the Ophthalmology Department of the General Hospital La Mancha Centro in the period 1996-2008. The identification of isolates was performed using the automated VITEK-2® and Api galleries (bioMérieux, Spain SA). The antimicrobial susceptibility was performed by the VITEK-2® system (bioMérieux, Spain SA), E-test strips (MIC Test Strip, Liofilchem, Italy) and Sensititre® YeastOne trading system (Trek Diagnostic Systems, Ohio, USA) for Candida species. RESULTS: Forty four (70%) of 63 cases of endophthalmitis were culture positive. Gram-positive bacteria were much more common than gram-negative bacteria in both postoperative endophthalmitis (POE) and post-traumatic endophthalmitis (PTE). Staphylococcus epidermidis was predominant in POE, while Bacillus sp. predominated in the PTE; furthermore, the 75% of total fungal isolates corresponded to postraumatic cases. The isolated strains showed 100% susceptibility to vancomycin, ceftazidime and amikacin, while resistance to ciprofloxacin was greater than 15%. The empirical antifungal therapy failed in 50% of cases. The visual prognosis was significantly less favorable in the PTE. CONCLUSIONS: Based on the susceptibility of our isolates, vancomycin, ceftazidime and amikacin are good choices for empirical treatment of endophthalmitis, unlike ciprofloxacin. We recommend conducting antifungal prophylaxis after penetrating ocular trauma in a rural environment.

[Spinal anesthesia versus general anesthesia in the surgical treatment of inguinal hernia. Cost-effectiveness analysis]. / Anestesia subaracnoidea y anestesia general en el tratamiento quirúrgico de la hernia inguinal en pacientes ambulatorios. Análisis comparativo de coste-efectividad.

OBJECTIVE: To compare the costs related to the clinical effectiveness of general anesthesia versus spinal anesthesia in inguinal hernioplasty ambulatory surgery. MATERIAL AND METHODS: An observational, retrospective cohort study measurement and analysis of cost-effectiveness, in the ambulatory surgery unit of a general hospital. All patients over 18 years of age diagnosed with primary inguinal hernia and scheduled for unilateral hernioplasty between January 2010 and December 2011 were included. Duration of anesthetic induction, length of stay in both the operating room, and in the post-anesthesia care unit, the anesthetic effectiveness (the incidence of adverse effects and the patient's comfort level), and variable economic costs associated with the use of drugs, as well as the use of human resources, were compared. RESULTS: The final analysis included 218 patients, 87.2% male, with a mean age of 53 years (range: 18-85 years). Of these, 139 (63.76%) received subarachnoid anesthesia and 79,(36.2%) general anesthesia. The length of time a patient remained in the post-anesthesia care unit was 337.6±160.2min in the subarachnoid anesthesia group, and 210.0±97.5min for the general anesthesia group (P<.001). Costs of drugs for general anesthesia were higher than that for subarachnoid anesthesia (86.2±8.3 vs. 18.7±7.2). The total cost difference between the 2 techniques was €115.8 more for subarachnoid anesthesia (P<.001). CONCLUSIONS: Both techniques showed similar effectiveness. The overall costs for subarachnoid anesthesia were greater than for the general. The cost-effectiveness of general anesthesia is better for outpatient inguinal hernia repair surgery.

Systematic review and meta-analysis of performance of second-trimester nasal bone assessment in detection of fetuses with Down syndrome.

OBJECTIVE: To review systematically the literature on diagnostic tests and performance of second-trimester sonographic assessment of nasal bone (NB) in identifying fetuses affected by Down syndrome. METHODS: A search of studies involving screening tests for NB evaluation and measurements was carried out in the main international bibliographic databases (MEDLINE, EMBASE and CINAHL). Those considered to be relevant were then subjected to critical reading, following Critical Appraisal Skills Programme (CASP) criteria, by at least three independent observers. All data were extracted and tabulated by two independent investigators. A statistical synthesis of sensitivity, specificity and likelihood ratios was performed using specific software (Meta-DiSc). RESULTS: From an initial list of 852 articles referring to ultrasound markers for Down syndrome, 207 relevant papers were selected. Following exclusions, 21 studies were included in the quantitative synthesis. The pooled estimates of positive and negative likelihood ratios were 40.08 (95% CI, 18.10-88.76) and 0.71 (95% CI, 0.64-0.79), respectively, for absent NB and 15.15 (95% CI, 8.15-28.16) and 0.47 (95% CI, 0.34-0.64), respectively, for hypoplastic NB. No relevant differences were found between the various means of defining nasal hypoplasia (multiples of the median (MoM) or percentiles). The biparietal diameter/nasal bone length (BPD/NBL) ratio showed somewhat higher sensitivity but lower specificity with a threshold effect. CONCLUSIONS: NB absence or hypoplasia show high specificity and low but acceptable sensitivity in identifying fetuses with Down syndrome. Screening performance is better with NB measurements as a function of MoM or percentiles rather than as the BPD/NBL ratio. Classification of women into various risk groups for Down syndrome does not affect diagnostic performance.

Quality of life and predictive factors in patients undergoing assisted reproduction techniques.

OBJECTIVES: To evaluate the quality of life (QOL) of a cohort of women undergoing assisted reproduction techniques (ART), to compare two QOL questionnaires [Short Form 36 (SF36) and FertiQoL], and to identify the predictive factors related to QOL. STUDY DESIGN: Women who received infertility medication from a hospital pharmacist during a one-year period were included in this study. Two standardized validated questionnaires - FertiQoL and SF36 - were used. Multivariate analyses were used to assess predictive factors for QOL. RESULTS: Sixty-one women participated in this study. Median QOL scores ranged from 58 to 100. Comparisons between the two questionnaires revealed lower QOL scores when using FertiQoL. Most correlations between the questionnaires were positive, and significant for the majority of SF36 mental dimensions. The major predictors of QOL were: accompanied to the pharmacist's visit by partner, nationality, ART (in vitro fertilization or artificial insemination), employment status (employed or unemployed), tobacco consumption, age, number of cycles, infertility factor and treatment results (pregnancy, no pregnancy or treatment cancellation). CONCLUSIONS: FertiQoL examines dimensions such as partner and social relationships. As such, it is recommended that FertiQoL should be used together with a short version of SF36 to investigate QOL among patients undergoing ART.

Lung cancer chemotherapy decisions in older patients: the role of patient preference and interactions with physicians

PURPOSE: Lung cancer chemotherapy decisions in patients ≥ 70 years old are complex because of toxicity, comorbidity and the limited data on patient preferences. We examined the relationships between preferences and chemotherapy use in this group of patients. METHODS AND PATIENTS: We used a questionnaire describing four hypothetical lung cancer treatment options. Eighty-three elderly (≥ 70 years old) lung cancer patients were informed about their diagnosis and therapeutic choices and then asked to choose one of the four options. Patients had previously been included in a prospective study to explore geriatric evaluation in an oncology unit and all had given written informed consent. RESULTS: Older patients (n=83) diagnosed with lung cancer (non-small- and small-cell lung cancer) from January 2006 to February 2008 were recruited from a single centre. The mean patient age was 77 years (range: 70-91). Eighty-one patients (97.6%) were men. Non-small-cell lung cancer (NSCLC) was the diagnosis in 63 patients (76%). Most patients selected active treatment (38.6% most survival benefit, 18% less survival benefit) and 31.3% selected no active treatment. Elderly lung cancer patients were significantly more likely to accept aggressive treatments despite high reported toxicities. Although most of the patients were symptomatic at diagnosis, the "symptom relief" option was chosen less frequently than the options that could prolong survival. Factors significantly related to patients' attitude toward chemotherapy were age (p<0.001), frailty (p=0.0039), depression and poor performance status (PS). CONCLUSION: Elderly lung cancer patients want to be involved in the decision-making process. Survival was the main treatment objective for more than half of the patients in this study. We have not found other published studies about elderly lung cancer patients' decisions about chemotherapy (AU)

A comparative study between gamma nail and percutaneous compression plating for the treatment of intertrochanteric hip fractures.

PURPOSE: Nowadays, the literature shows better results in the treatment of intertrochanteric (AO/OTA 31.A1-A2) hip fractures with dynamic hip screw (DHS) compared with gamma nail (GN). Besides, percutaneous compression plate (PCCP) gives results which are better or similar to those obtained with DHS. But only two reports compare the results between PCCP and GN. The aim of this trial is to compare the outcome of treatment of these fractures with either a PCCP or a GN. METHODS: A retrospective trial with 414 patients over 60 years of age treated in our institution for 6 years, with a minimum follow-up of 1 year, was performed to compare the outcome of a PCCP (240) with a GN (174). RESULTS: The post-operative hospital stay was 2 days longer in the GN group compared to the PCCP group (p < 0.001). The post-operative haemoglobin serum level was slightly lower in the GN group (relative risk (RR) -0.28, 95% confidence interval (CI): -0.02 to -0.54, p = 0.036) and the transfusion requirement was lower in the PCCP group (GN 53.4% vs. PCCP 33.8%, p < 0.001). The procedure-related complications rate was higher in the GN group (9.8 vs. 5%, p = 0.06). CONCLUSIONS: PCCP has lower overall economical cost and blood transfusional requirements for a similar or better outcome in terms of procedure-related complications.

[Two-year diagnostic stability and prognosis in acute psychotic episodes]. / Estabilidad diagnóstica y pronóstico a dos años de episodios psicóticos agudos.

INTRODUCTION: The term acute psychosis represents a group of rapid-onset and recovery psychosis. The current diagnostic criteria are not uniform and represent a heterogeneous set of psychoses. Although their form of clinical presentation may be similar, their evolution and prognosis are very different. It is very important to detect the possible factors of chronicity in order to make an early intervention and thus to diminish the negative consequences of the disease. METHODOLOGY: We conducted a 2 year prospective study in 48 patients diagnosed with acute psychosis in their first admission. Data was collected on the evolution and follow-up of the patient in the Mental Health Unit and the sociodemographic and clinical factors of the psychotic index episode that could predict a change in the diagnosis during the two years follow-up were analyzed. RESULTS: None of the sociodemographic or clinical variables studied could predict a change in the diagnosis, except for the presence of a control delusion during the index episode. The diagnosis of schizophreniform or not otherwise specified psychotic disorders predicts an evolution towards schizophrenia or affective psychosis while a brief or substance-induced psychotic episode has a better prognosis, with a tendency to maintain the same diagnosis in the 2 years of follow-up. CONCLUSION: After 2 years of follow-up, an significant number of the patients initially diagnosed of acute psychosis evolved towards a diagnosis of schizophrenia or affective psychosis in a difficult-to-predict way.

Estabilidad diagnóstica y pronóstico a 2 años de episodios psicóticos agudos / Two-year diagnostic stability and prognosis in acute psychotic episodes

Introducción. El término psicosis aguda representa un grupo de psicosis de inicio y resolución rápida. Los criterios diagnósticos actuales adolecen de uniformidad, representando un conjunto heterogéneo de psicosis. Aunque la forma de presentación clínica puede ser similar, la evolución y el pronóstico pueden ser muy diferentes. La detección de posibles factores de riesgo de cronicidad es de especial importancia, pudiendo realizar una intervención precoz y así minimizar las consecuencias negativas de la enfermedad. Metodología. Estudio prospectivo a 2 años de una muestra final de 48 pacientes diagnosticados de psicosis aguda en el ingreso. Se recoge información sobre la evolución y seguimiento del paciente en la Unidad de Salud Mental y analizan los factores sociodemográficos y clínicos del episodio psicótico índice, que puedan predecir un cambio en el diagnóstico durante el período de estudio. Resultados. Ninguna de las variables sociodemográficas o clínicas estudiadas presenta capacidad de predecir un cambio en el diagnóstico, salvo la presencia de un delirio de control durante el episodio índice. El diagnóstico de trastorno esquizofreniformeo psicótico no especificado pronostica una evolución hacia esquizofrenia o psicosis afectiva, mientras el trastorno psicótico breve o inducido por sustancias presentan un mejor pronóstico, tendiendo a mantener el mismo diagnóstico a los 2 años. Conclusión. A los 2 años, de una forma difícilmente predecible, una fracción importante de los pacientes diagnosticados inicialmente de psicosis aguda evoluciona hacia un diagnóstico de esquizofrenia o psicosis afectiva (AU)

Introduction. The term acute psychosis represents a group of rapid-onset and recovery psychosis. The current diagnostic criteria are not uniform and represent a heterogeneous set of psychoses. Although their form of clinical presentation may be similar, their evolution and prognosis are very different. It is very important to detect the possible factors of chronicity in order to make an early intervention and thus to diminish the negative consequences of the disease. Methodology. We conducted a 2 year prospective study in 48 patients diagnosed with acute psychosis in their first admission. Data was collected on the evolution and follow-up of the patient in the Mental Health Unit and the sociodemographic and clinical factors of the psychotic index episode that could predict a change in the diagnosis during the two years follow-up were analyzed. Results. None of the sociodemographic or clinical variables studied could predict a change in the diagnosis, except for the presence of a control delusion during the index episode. The diagnosis of schizophreniform or not otherwise specified psychotic disorders predicts an evolution towards schizophrenia or affective psychosis while a brief or substance-induced psychotic episode has a better prognosis, with a tendency to maintain the same diagnosis in the 2 years of follow-up. Conclusion. After 2 years of follow-up, an significant number of the patients initially diagnosed of acute psychosis evolved towards a diagnosis of schizophrenia or affective psychosis in a difficult-to-predict way (AU)

[Agreement in the determination of electrolytes in samples of serum and plasma. Stability of these samples kept for 2 hours at room temperature with uncovered tubes]. / Détermination des électrolytes dans des échantillons de sérum et de plasma, et stabilité dans des tubes ouverts pendant 2 heures à température ambiante.

UNLABELLED: The determination of electrolytes in the clinical laboratories is carried out in samples of serum or plasma in situations that tubes remain open during a lingering time. OBJECTIVE: To estimate the agreement and the interchangeability in the determination of electrolytes for three types of tubes (serum with separator, plasma with and without separator) in samples that remain at room temperature and open up to two hours. MATERIAL AND METHODS: Samples of 36 voluntary patients were selected determining the levels of sodium, potassium, chlorine, calcium, magnesium and phosphate in the three tubes on time 0 (basal), 60 and 120 minutes. The agreement was estimated by means of the intraclass correlation coefficient (ICC) and the interchangeability of results by means of lineal regression. RESULTS: Agreement among the samples was very high with ICC higher than 0.9 in all basal determinations except for the potassium for which the presence of a constant systematic error was detected between serum and two tubes of plasma. The stability of the parameters is good in all the samples. CONCLUSIONS: It is possible the use of different types of tubes in the determination of electrolytes under the working conditions of the clinical laboratories. The determination of potassium needs to be corrected before the exchange of results obtained with serum and plasma. The stability in the two first hours is good in all the cases.

Elección de neuroléptico y respuesta clínica en psicosis aguda: un estudio comparativo de risperidona frente a otros neurolépticos / Neuroleptics election and clinical outcomes in acute psychosis: a comparative study of risperidone versus other neuroleptics

Introducción: El diagnóstico de psicosis aguda se encuentra sometido a una permanente revisión, siendo sus criterios actuales (DSM-IV e ICD-10) insuficientes. Los objetivos son determinar la existencia de un perfil clínico a la hora de la elección del neuroléptico y la efectividad de estos en la psicosis aguda. Material y método: Se estudian 54 pacientes ingresados, que al alta son diagnosticados de psicosis aguda (trastorno psicótico breve, trastorno psicótico no especificado, trastorno psicótico inducido por drogas o trastorno psicótico esquizofreniforme). Se analizan dos grupos: tratados con risperidona (n = 34) o con otros neurolépticos: olanzapina, haloperidol y pimocide (n = 20). Resultados: En los episodios psicóticos agudos con clínica depresiva suele elegirse la risperidona y cuando se acompaña de clínica de aspecto maniaco y de agitación-agresividad se utilizan otros neurolépticos. La respuesta clínica en ambos grupos fue similar para todos los indicadores analizados. En los pacientes tratados con risperidona se prescribe menos medicación antiparkinsoniana. Conclusión: A pesar de un perfil clínico diferente la efectividad clínica de ambos grupos de tratamiento fue equivalente (AU)

Effects of time, temperature and blood cell counts on levels of lactate in heparinized whole blood gas samples.

OBJECTIVE: To investigate whether lactate levels may vary in relation to time, substrate concentration and blood cells counts. METHODS: In this study 110 samples from the daily clinical routine blood samples were collected. Determinations of lactate were made at different times where the samples had not been left for more than 120 min at room temperature (24 degrees C) or in the fridge (4 degrees C). The influence of glucose and blood cells on lactate production was also estimated. The rate in change of concentration (slope) and the increase expected at the beginning (intercept) were estimated through linear regression using a longitudinal marginal method. RESULTS: The time-related change in lactate was significantly higher at room temperature (0.012 mmol L(-1) min(-1)) than at 4 degrees C (0.0035 mmol L(-1) min(-1)) (p<0.0001). There was a significantly positive relationship between blood cells (mainly leucocytes) and the rate of reaction at room temperature. CONCLUSIONS: A delay in the processing of a whole blood sample of more than 15 min at room temperature or an hour in the fridge entails an important overestimation of the initial lactate levels. Pronounced leucocytosis (higher than 6 x 10(10)/L) meaningfully cut down the stability period (10 min).