RESUMO
Nosocomial infections (NIs) currently represent one of the main health problems for both professionals and health authorities. These continue to cause high mortality, which has led to its study and the development of prevention measures to reduce the impact and minimise the incidence. OBJECTIVE: Analysis of the epidemiological aspects of NIs in a tertiary hospital. MATERIALS AND METHODS: A5-year retrospective study in which NIs verified at admission, their prevalence, associated risk factors and their location were analysed and classified. The data were collected through cross sections for hospitalisation episodes, using standardised forms for them issued by the Spanish Society of Preventive Medicine and Public Health. RESULTS: 2905 episodes of hospitalised patients were analysed, where 52.94% were men. The NI acquired in the centre was the most prevalent of all registered, having registered in the last year 53 cases. The infections acquired in the study income remained stable throughout the study, although there was a slight decrease in the last two years. CONCLUSIONS: The multidisciplinary nature of the NIs allows to improve their approach, reducing the harmful effects on health.
RESUMO
Los compuestos de platino son ampliamente utilizados en diferentes tumores, siendo carboplatino el indicado en carcinoma de ovario. La principal toxicidad limitante de dosis de carboplatino es la trombopenia, sin embargo, en ocasiones presenciamos reacciones de hipersensibilidad que, aunque no es un hecho demasiado frecuente (8-16%), sí puede ser grave. Por ello, han sido desarrollados protocolos de desensibilización. Comunicamos el caso de una paciente intervenida quirúrgicamente de un carcinoma seroso papilar de ovario (estadio IIIC) y que posteriormente recibió quimioterapia adyuvante con carboplatino y paclitaxel. Tras veintidós meses de intervalo libre de enfermedad, mostró recaída abdominal irresecable, por lo que se instauró de nuevo tratamiento con carboplatino y paclitaxel. Durante la administración del segundo ciclo, manifestó reacción grave de hipersensibilidad a carboplatino. Se intentó esquema de desensibilización sin éxito, no pudiendo continuar con dicho tratamiento y obligando a iniciar segunda línea con trabectedina y adriamicina liposomal pegilada (AU)
Platinum compounds are widely used in different tumors, being carboplatin indicated in ovarian carcinoma. The main carboplatin-dose limiting toxicity is the thrombocytopenia, however, sometimes we have seen hypersensitivity reactions that, although it is not a fact too often (8-16%), can be severe. For this reason, desensitization protocols have been developed. We report the case of a patient intervened surgically from a papillary serous carcinoma of ovary (stage IIIC) and who later received adjuvant chemotherapy with carboplatin and paclitaxel. After twenty-two months of disease-free interval, she showed unresectable abdominal relapse, so it was again treated with carboplatin and paclitaxel. During the administration of the second cycle, said severe hypersensitivity reaction to carboplatin. Attempted to desensitization unsuccessfully, can not continue with this treatment scheme and forcing to start second line with trabectedin and pegylated liposomal adriamycin (AU)
