1.
Chem Commun (Camb)
; 58(51): 7200-7203, 2022 Jun 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35671164
RESUMO
A photoredox/copper cocatalyzed domino cyclization of oxime esters with TMSCN has been developed. A range of structurally novel tetrasubstituted pyrazines have been obtained. This method features high bond-forming efficiency, high step economy, broad substrate scope, and gram-scale synthesis. Moreover, preliminary bioactivity evaluation of pyrazine products shows their promising antifungal activities.