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1.
iScience ; 26(4): 106404, 2023 Apr 21.
Artigo em Inglês | MEDLINE | ID: mdl-37034997

RESUMO

The manufacturing and consumption of plastic products have steadily increased over the past decades due to rising global demand, resulting not only in the depletion of petroleum resources but also increased environmental pollution due to the non-biodegradable nature of conventional plastics. Moreover, despite being introduced into the market as an alternative to conventional petroleum-based plastics, biobased plastics are mainly manufactured from agricultural crop-based sources, which has negative impacts on the environment and the livelihoods of people. Marine-derived bioplastics are becoming a promising and cost-effective solution to the rising demand for plastic products. The physicochemical, biological, and degradation properties of marine-derived bioplastics have made them promising substances for many applications. However, more research is required for their large-scale implementation. Therefore, this review summarizes the raw materials of marine-derived bioplastics such as algae, animals, and microorganisms, as well as their extraction processes and properties. These insights could thus accelerate the production of marine-derived bioplastics as a novel alternative to prevailing bioplastics by taking advantage of marine biomass.

2.
Mar Drugs ; 20(10)2022 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-36286477

RESUMO

Coagulation is a potential defense mechanism that involves activating a series of zymogens to convert soluble fibrinogen to insoluble fibrin clots to prevent bleeding and hemorrhagic complications. To prevent the extra formation and diffusion of clots, the counterbalance inhibitory mechanism is activated at levels of the coagulation pathway. Contrariwise, this system can evade normal control due to either inherited or acquired defects or aging which leads to unusual clots formation. The abnormal formations and deposition of excess fibrin trigger serious arterial and cardiovascular diseases. Although heparin and heparin-based anticoagulants are a widely prescribed class of anticoagulants, the clinical use of heparin has limitations due to the unpredictable anticoagulation, risk of bleeding, and other complications. Hence, significant interest has been established over the years to investigate alternative therapeutic anticoagulants from natural sources, especially from marine sources with good safety and potency due to their unique chemical structure and biological activity. This review summarizes the coagulation cascade and potential macromolecular anticoagulants derived from marine flora and fauna.


Assuntos
Anticoagulantes , Trombose , Humanos , Anticoagulantes/farmacologia , Anticoagulantes/uso terapêutico , Heparina/farmacologia , Hemorragia/induzido quimicamente , Hemorragia/tratamento farmacológico , Hemorragia/prevenção & controle , Trombose/tratamento farmacológico , Fibrina , Fibrinogênio , Precursores Enzimáticos
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