Regioselective formation of interlocked dicarba bridges in naturally occurring cyclic peptide toxins using olefin metathesis.

Bis-dicarba analogues of native dicystine-containing alpha-conotoxin Rg1A, an analgesic peptide isolated from cone snail venom, were constructed on resin using a regioselective metathesis-hydrogenation strategy.

A highly enantioselective synthesis of cyclic alpha-amino acids involving a one-pot, single catalyst, tandem hydrogenation-hydroformylation sequence.

Tandem enantioselective hydrogenation followed by a hydroformylation-cyclisation sequence leading to cyclic alpha-amino acids with ee's > 95% can be achieved in a single pot, one catalyst system by successive reactions of prochiral dienamide esters with H2 followed by H2/CO using Rh(I)-DuPHOS.