[Age dynamics of secretory, absorptive, buffer ability of the mucosa inside the human nose].

The problem of age-related functional changes of organs and systems of the human body is one of the urgent problems of modern physiology and gerontology. The most important, complex system of human body is respiratory system, especially its «first line of defense¼ - the nasal cavity. Functional parameters of the nasal cavity undergo a number of specific changesat the stages of postnatal ontogenesis, the study of which has not only scientific value but also practical value for experimental physiology and clinical medicine. The article presents data on the age dynamics and adaptability of such functional parameters of the mucous membrane of the nasal cavity of the person, as secretory and suction activity, the air heater function, the buffer properties by endonasal secret. These indicators are examined at the stages of postnatal development in a comparative perspective based on the study of the age gradients.

[Age peculiar by endonasal homeostasis in humans.]

The state of protective functions of the nasal cavity determines its homeostasis. At the stages of postnatal development and involution of functional parameters by endonasal homeostasis undergo a number of specific changes, the study of which has not only scientific value but also practical value for experimental physiology and clinical medicine. The article presents data on the age dynamics of functional indicators by endonasal homeostasis of human as buffer properties and morphological features of nasal secret. These indicators are examined at the stages of postnatal development in a comparative perspective based on the study of the age gradients and the position of the doctrine of entropy.

[The functional state of nasal cavity in the aspect of structural-functional changes of the human organism in postnatal ontogenesis.]

Nasal cavity - «the primary line of defense¼ and a major division of the respiratory tract. A variety of functional areas and regions, structural formations of the nasal cavity allows, at the present stage of development of biology and medicine, consider it as a complex functional subsystem in the structure of the respiratory system. The age transformations of morphological and functional parameters of the nasal cavity are polymorphic and specific. An important aspect of developmental physiology of the respiratory system is a study of the relationship of these changes with morphological and functional transformations of other systems of the body. The article presents the results of the analysis of such contingency-for example, by endonasal correlations with amount of blood flow hemodynamics and functional state of the autonomic nervous system, respiratory function of the nasal cavity and respiratory system, as well as other functions of the nasal cavity and their relationship with general growth processes, critical periods of development and involution. In the process of this analysis revealed a close correlation with complex changes of the morphofunctional parameters of the systems of the human body, most pronounced during in critical periods of postnatal ontogenesis.